Studying Risk Factors for Type 2 Diabetes in Young People
Studies how blood sugar and insulin change in obese teens at risk of diabetes.
Plain-language title generated from the registry record
Registry title: DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Key facts
- Where
- Aurora, Baltimore, Birmingham, Boston, Brooklyn, Charlotte, Cincinnati, Columbus, Garden City, Houston, Los Angeles, New York, Oklahoma City, Philadelphia, Phoenix, Shiprock, St. Petersburg, The Bronx, and Winston-Salem, United StatesSee the 20 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 8 and 15 years old?
Source: NCT06525259, who can take part
Where in United States
- Children's Hospital ColoradoAurora, United StatesTaking people
- Johns Hopkins University School Of MedicineBaltimore, United StatesTaking people
- University of Alabama at BirminghamBirmingham, United StatesTaking people
- Boston Children's/Joslin Diabetes Center/Massachusetts General HospitalBoston, United StatesTaking people
- NYU Langone Health - BrooklynBrooklyn, United StatesTaking people
- Atrium HealthCharlotte, United StatesTaking people
- Cincinnati Children's HospitalCincinnati, United StatesTaking people
- Nationwide Children's HospitalColumbus, United StatesTaking people
- NYU Langone Health- Long IslandGarden City, United StatesTaking people
- Baylor College of Medicine / Texas Children'sHouston, United StatesTaking people
- Children's Hospital Los AngelesLos Angeles, United StatesTaking people
- NYU Langone Health ManhattanNew York, United StatesTaking people
- The University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Children's Hospital of PhiladelphiaPhiladelphia, United StatesTaking people
- Arizona State UniversityPhoenix, United StatesTaking people
- Phoenix Children'sPhoenix, United StatesTaking people
- Colorado Navajo NationShiprock, United StatesTaking people
- Johns Hopkins All Children's HospitalSt. Petersburg, United StatesTaking people
- Albert Einstein College of MedicineThe Bronx, United StatesTaking people
- Wake Forest UniversityWinston-Salem, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- George Washington University
- Trial code
- NCT06525259
- Record updated
- 7 May 2026
- Original description
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.Read full original descriptionShow less
DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.
Inclusion: Screening will occur to enrich the yield of individuals who are highly predisposed to develop youth-onset T2D and include those with all of the following criteria:; Overweight or obesity with BMI ≥85th percentile; Age 8-13 year for girls, 9-15 year for boys (inclusion younger for girls as puberty tends to start a year earlier in girls); Tanner Stage 2, 3, or 4; Elevated HbA1c 5.5-6.4%.
Exclusion: Prior treatment with insulin; Use of glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications in the 6 weeks prior to enrollment; Planning treatment with glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications; Conditions predisposing to diabetes or altering the trajectory of puberty; Major systemic organ disease; History of bariatric surgery or currently planning bariatric surgery; Diabetes based on history, or HbA1c ≥6.5% in the medical record or at screening; Medications affecting glucose dynamics during the screening and enrollment period; Use of metformin or any glucose lowering medication for a reason other than treatment of diabetes (e.g., for PCOS) in the 6 weeks prior to enrollment; Planning treatment with metformin or any glucose lowering medication or planning to use such medications for a reason other than treatment of diabetes (e.g., for PCOS); Blood disorders impacting HbA1c (e.g., anemia, hemoglobin variants); An individual who meets any of the following criteria will be excluded from participation:; Unable/unwilling to provide consent/participate fully; Known syndromic/monogenic obesity; Current pregnancy or currently planning pregnancy; Use of GnRH agonist, estrogen, or testosterone; Individuals who do not speak English or Spanish, given validation of the questionnaires to be utilized.