Taking people in United StatesPhase 3

Tests efruxifermin in adults with cirrhosis caused by fatty liver disease

Tests efruxifermin against a placebo in adults with cirrhosis from MASH.

Plain-language title generated from the registry record
Registry title: A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

Key facts

Where: Akron, Amarillo, Arlington, Atlanta, Aurora, Austin, Baltimore, Bastrop, Bellaire, Bethesda, Birmingham, Bradenton, Brandon, Brownsville, Buffalo, Chandler, Chapel Hill, Charleston, Charlotte, Chicago, Clarksville, Clinton Township, Colorado Springs, Columbia, Conway, Coronado, Corpus Christi, Covington, Cutler Bay, Dallas, Daytona Beach, Denison, Doral, Dothan, Durham, Edinburg, Englewood, Escondido, Fayetteville, Flagstaff, Flowood, Folsom, Fort Myers, Fort Sam Houston, Fort Worth, Fountain Valley, Gainesville, Garland, Hammond, Henderson, Hermitage, Hershey, Hialeah Gardens, Houma, Houston, Indianapolis, Inverness, Jackson, Jonesboro, Kansas City, Kingwood, Lady Lake, Lafayette, Lakewood Rch, Lancaster, Largo, Las Vegas, Lehigh Acres, Little Rock, Long Beach, Los Angeles, Louisville, Madison, Manhasset, Margate, Marietta, Marrero, Metairie, Miami, Miami Gardens, Morehead City, Naples, Nashville, New Haven, New Port Richey, New York, Newport Beach, Norfolk, North Little Rock, Novi, Ocala, Oklahoma City, Orange, Orlando, Pasadena, Pembroke Pines, Peoria, Pharr, Philadelphia, Pittsburgh, Raleigh, Redwood City, Richmond, Riverview, Roanoke, Rochester, Sacramento, San Antonio, San Francisco, San Jose, Sarasota, Scottsdale, Seattle, Shreveport, Snellville, Somers Point, South Bend, South Dartmouth, Southfield, Sparta, Springboro, St Louis, Statesville, Sugar Land, Summerville, Tarzana, Temple Terrace, Topeka, Tucson, Vancouver, Venice, Viera, Waco, Washington D.C., Webster, West Des Moines, West Monroe, Westlake, Weston, Wichita Falls, and Zephyrhills, United StatesSee the 141 sites
Phase: Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

Source: NCT06528314, who can take part

Where in United States

AkronAkron, United StatesTaking people
AmarilloAmarillo, United StatesNo longer taking part
ArlingtonArlington, United StatesTaking people
AtlantaAtlanta, United StatesTaking people
AuroraAurora, United StatesTaking people
AustinAustin, United StatesTaking people
BaltimoreBaltimore, United StatesTaking people
BastropBastrop, United StatesTaking people
BellaireBellaire, United StatesTaking people
BethesdaBethesda, United StatesTaking people
BirminghamBirmingham, United StatesTaking people
BradentonBradenton, United StatesTaking people
BrandonBrandon, United StatesTaking people
BrownsvilleBrownsville, United StatesTaking people
BuffaloBuffalo, United StatesTaking people
ChandlerChandler, United StatesTaking people
Chapel HillChapel Hill, United StatesTaking people
CharlestonCharleston, United StatesTaking people
CharlotteCharlotte, United StatesTaking people
ChicagoChicago, United StatesTaking people
ClarksvilleClarksville, United StatesTaking people
Clinton TownshipClinton Township, United StatesNo longer taking part
Colorado SpringsColorado Springs, United StatesTaking people
ColumbiaColumbia, United StatesTaking people
ConwayConway, United StatesNo longer taking part
CoronadoCoronado, United StatesTaking people
Corpus ChristiCorpus Christi, United StatesTaking people
CovingtonCovington, United StatesTaking people
Cutler BayCutler Bay, United StatesTaking people
DallasDallas, United StatesTaking people
Daytona BeachDaytona Beach, United StatesNo longer taking part
DenisonDenison, United StatesTaking people
DoralDoral, United StatesTaking people
DothanDothan, United StatesTaking people
DurhamDurham, United StatesTaking people
EdinburgEdinburg, United StatesTaking people
EnglewoodEnglewood, United StatesTaking people
EscondidoEscondido, United StatesTaking people
FayettevilleFayetteville, United StatesTaking people
FlagstaffFlagstaff, United StatesNo longer taking part
FlowoodFlowood, United StatesTaking people
FolsomFolsom, United StatesTaking people
Fort MyersFort Myers, United StatesTaking people
Fort Sam HoustonFort Sam Houston, United StatesTaking people
Fort WorthFort Worth, United StatesNo longer taking part
Fountain ValleyFountain Valley, United StatesTaking people
GainesvilleGainesville, United StatesTaking people
GarlandGarland, United StatesNo longer taking part
HammondHammond, United StatesTaking people
HendersonHenderson, United StatesTaking people
HermitageHermitage, United StatesTaking people
HersheyHershey, United StatesTaking people
Hialeah GardensHialeah Gardens, United StatesTaking people
HoumaHouma, United StatesTaking people
HoustonHouston, United StatesTaking people
IndianapolisIndianapolis, United StatesTaking people
InvernessInverness, United StatesTaking people
JacksonJackson, United StatesTaking people
JonesboroJonesboro, United StatesNo longer taking part
Kansas CityKansas City, United StatesTaking people
KingwoodKingwood, United StatesTaking people
Lady LakeLady Lake, United StatesNo longer taking part
LafayetteLafayette, United StatesTaking people
Lakewood RchLakewood Rch, United StatesTaking people
LancasterLancaster, United StatesTaking people
LargoLargo, United StatesTaking people
Las VegasLas Vegas, United StatesTaking people
Lehigh AcresLehigh Acres, United StatesTaking people
Little RockLittle Rock, United StatesTaking people
Long BeachLong Beach, United StatesTaking people
Los AngelesLos Angeles, United StatesTaking people
LouisvilleLouisville, United StatesTaking people
MadisonMadison, United StatesTaking people
ManhassetManhasset, United StatesTaking people
MargateMargate, United StatesTaking people
MariettaMarietta, United StatesTaking people
MarreroMarrero, United StatesTaking people
MetairieMetairie, United StatesTaking people
MiamiMiami, United StatesTaking people
Miami GardensMiami Gardens, United StatesTaking people
Morehead CityMorehead City, United StatesTaking people
NaplesNaples, United StatesTaking people
NashvilleNashville, United StatesTaking people
New HavenNew Haven, United StatesTaking people
New Port RicheyNew Port Richey, United StatesTaking people
New YorkNew York, United StatesTaking people
Newport BeachNewport Beach, United StatesTaking people
NorfolkNorfolk, United StatesTaking people
North Little RockNorth Little Rock, United StatesTaking people
NoviNovi, United StatesTaking people
OcalaOcala, United StatesTaking people
Oklahoma CityOklahoma City, United StatesTaking people
OrangeOrange, United StatesTaking people
OrlandoOrlando, United StatesNo longer taking part
PasadenaPasadena, United StatesTaking people
Pembroke PinesPembroke Pines, United StatesTaking people
PeoriaPeoria, United StatesTaking people
PharrPharr, United StatesNo longer taking part
PhiladelphiaPhiladelphia, United StatesTaking people
PittsburghPittsburgh, United StatesTaking people
RaleighRaleigh, United StatesTaking people
Redwood CityRedwood City, United StatesTaking people
RichmondRichmond, United StatesTaking people
RiverviewRiverview, United StatesTaking people
RoanokeRoanoke, United StatesTaking people
RochesterRochester, United StatesTaking people
SacramentoSacramento, United StatesTaking people
San AntonioSan Antonio, United StatesTaking people
San FranciscoSan Francisco, United StatesTaking people
San JoseSan Jose, United StatesTaking people
SarasotaSarasota, United StatesTaking people
ScottsdaleScottsdale, United StatesTaking people
SeattleSeattle, United StatesTaking people
ShreveportShreveport, United StatesTaking people
SnellvilleSnellville, United StatesNo longer taking part
Somers PointSomers Point, United StatesTaking people
South BendSouth Bend, United StatesTaking people
South DartmouthSouth Dartmouth, United StatesTaking people
SouthfieldSouthfield, United StatesTaking people
SpartaSparta, United StatesTaking people
SpringboroSpringboro, United StatesTaking people
St LouisSt Louis, United StatesTaking people
StatesvilleStatesville, United StatesTaking people
Sugar LandSugar Land, United StatesNo longer taking part
SummervilleSummerville, United StatesTaking people
TarzanaTarzana, United StatesTaking people
Temple TerraceTemple Terrace, United StatesTaking people
TopekaTopeka, United StatesTaking people
TucsonTucson, United StatesTaking people
VancouverVancouver, United StatesTaking people
VeniceVenice, United StatesNo longer taking part
VieraViera, United StatesNo longer taking part
WacoWaco, United StatesTaking people
Washington D.C.Washington D.C., United StatesTaking people
WebsterWebster, United StatesTaking people
West Des MoinesWest Des Moines, United StatesTaking people
West MonroeWest Monroe, United StatesTaking people
WestlakeWestlake, United StatesTaking people
WestonWeston, United StatesTaking people
Wichita FallsWichita Falls, United StatesTaking people
ZephyrhillsZephyrhills, United StatesTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: Akero Therapeutics, Inc
Trial code: NCT06528314
Record updated: 13 October 2026
Original description: This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.Read full original descriptionShow less
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.
Inclusion: Cohort 1: Biopsy proven compensated cirrhosis (fibrosis stage 4) due to NASH/MASH and NAS score of >=3 (at least 1 in each category) or evidence of steatosis and 2 current features of metabolic comorbidities; Cohort 2: Biopsy proven or non-invasively diagnosed compensated cirrhosis (fibrosis stage 4) due to NASH/MASH.
Exclusion: Any current or prior history of decompensated liver disease; Other inclusion and exclusion criteria may apply; Type 1 diabetes or unstable Type 2 diabetes; Other causes of liver disease based on medical history and/or liver histology and/or central laboratory results.
ClinicalTrials.gov NCT06528314