Tests genome sequencing and digital twins for high cholesterol in Emiratis
Tests whole genome sequencing to guide care for adults with inherited high cholesterol.
Plain-language title generated from the registry record
Registry title: Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis
Key facts
- Where
- Abu Dhabi, United Arab EmiratesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Source: NCT06535542, who can take part
Where in United Arab Emirates
- Abu Dhabi Health Research CenterAbu Dhabi, United Arab EmiratesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Abu Dhabi Health Services Company
- Trial code
- NCT06535542
- Record updated
- 25 March 2025
- Original description
This pilot study investigates integrating whole genome sequencing and digital twin technology for managing hypercholesterolemia in Abu Dhabi clinics. It aims to establish protocols for larger future studies and incorporate genomic insights into routine medical care.Read full original descriptionShow less
A Randomized Trial of Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis
This pilot study investigates integrating whole genome sequencing and digital twin technology for managing hypercholesterolemia in Abu Dhabi clinics. It aims to establish protocols for larger future studies and incorporate genomic insights into routine medical care.
Inclusion: Patients with 2 or more LDL-C levels greater than 190 mg/dL or 5.0 mmol/L in the past 12 months; Undiagnosed patients meeting Possible, Probable or Definitive FH criteria according to Dutch Lipid Clinic Network (DLCN) criteria (Eur Heart J. 2011 Jul;32(14):1769-818. doi: 10.1093/eurheartj/ehr158. Epub 2011 Jun 28.); Patients who have not been on anti-lipidemic medication in the past 3 months; Ages 18-55; Emirati national; All patients must be fluent in English or Arabic.
Exclusion: Patients with a previous diagnosis of FH; Patients with a progressive debilitating illness; Patient with untreated hypothyroidism, history of proteinuria, obstructive liver disease, chronic renal failure, human immunodeficiency virus infection, or on immunosuppressant or steroid or psychiatric medications; - Patients who do not meet the above criteria; Patients with untreated clinical anxiety or depression (as measured by a Hospital Anxiety and Depression Scale (HADS) score of ≥ 16 on the depression subscale); Patients who are pregnant.