Tests pozelimab and cemdisiran in adults with geographic atrophy from macular degeneration
Tests two experimental injected drugs against placebo in adults with advanced macular degeneration.
Plain-language title generated from the registry record
Registry title: A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Key facts
- Where
- Abilene, Albuquerque, Asheville, Augusta, Aurora, Austin, Baltimore, Bellaire, Bethlehem, Beverly Hills, Bonita Springs, Boston, Brentwood, Bristol, Burlington, Carmel, Cary, Chandler, Cherry Hill, Chevy Chase, Chicago, Cincinnati, Cleveland, Colorado Springs, Columbus, Coral Springs, Dallas, Denver, Dublin, Durango, Edmond, Encino, Erie, Eugene, Fairfax, Fort Lauderdale, Fort Myers, Fort Worth, Fresno, Fullerton, Grand Blanc, Greenville, Hagerstown, Hickory, Hudson, Huntington Beach, Irvine, Jacksonville, Katy, La Jolla, Ladson, Lakeland, Lakewood, Lemont, Lenexa, Liverpool, Long Beach, Longmont, Los Angeles, Louisville, Lynchburg, Madison, Manchester, Marietta, McAllen, Metairie, Modesto, Morgantown, Mountain View, Mt. Pleasant, Naples, Nashua, Nashville, New Orleans, New York, Oak Park, Orlando, Oxnard, Palm Beach Gardens, Palm Desert, Pasadena, Philadelphia, Phoenix, Pinellas Park, Plano, Portland, Poughkeepsie, Poway, Rapid City, Redlands, Richmond, Riverside, Round Rock, Rowland Heights, Sacramento, Salt Lake City, San Antonio, San Francisco, Santa Ana, Sarasota, Scottsdale, Sewickley, Sioux Falls, Southaven, Southlake, Spokane, Springdale, Springfield, St Louis, St. Petersburg, Tampa, Teaneck, The Woodlands, Toms River, Torrance, Tucson, Tulsa, Tyler, Wake Forest, Waltham, Waterford, West Columbia, West Jordan, West Monroe, Winston-Salem, Winter Haven, and Worcester, United StatesSee the 160 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 85 years old?
Source: NCT06541704, who can take part
Where in United States
- Retina Research Institute of TexasAbilene, United StatesTaking people
- Vision Research Center at Eye Associates of New MexicoAlbuquerque, United StatesTaking people
- University of New Mexico HSCAlbuquerque, United StatesNo longer taking part
- Western Carolina Retinal AssociatesAsheville, United StatesNo longer taking part
- Southeast Retina CenterAugusta, United StatesTaking people
- University of ColoradoAurora, United StatesTaking people
- Austin Research Center for RetinaAustin, United StatesTaking people
- Austin Retina AssociatesAustin, United StatesTaking people
- Austin Clinical Research, LLCAustin, United StatesNo longer taking part
- The Retina Care CenterBaltimore, United StatesTaking people
- Retina Consultants TexasBellaire, United StatesTaking people
- Mid Atlantic RetinaBethlehem, United StatesTaking people
- Retina Specialists of Beverly Hills- Department of OphthalmologyBeverly Hills, United StatesTaking people
- Retina-Vitreous Associates Medical GroupBeverly Hills, United StatesTaking people
- Advanced Retina Institute-OphthalmologyBonita Springs, United StatesTaking people
- Massachusetts Eye and Ear InfirmaryBoston, United StatesTaking people
- Opthalmic Consultants of BostonBoston, United StatesTaking people
- Sight MDBrentwood, United StatesTaking people
- Southeastern Retina AssociatesBristol, United StatesTaking people
- University of VermontBurlington, United StatesTaking people
- Midwest Eye InstituteCarmel, United StatesTaking people
- NC Retina AssociatesCary, United StatesTaking people
- Barnet Dulaney Perkins Eye Center-OphthamalogyChandler, United StatesTaking people
- Mid Atlantic Retina - Cherry HillCherry Hill, United StatesTaking people
- The Retina Group of WashingtonChevy Chase, United StatesTaking people
- Retinal Vitreal ConsultantsChicago, United StatesTaking people
- The University Of ChicagoChicago, United StatesTaking people
- University of Illinois at ChicagoChicago, United StatesTaking people
- Cincinnati Eye InstituteCincinnati, United StatesTaking people
- Cole Eye Institute - Cleveland ClinicCleveland, United StatesTaking people
- University Hospitals Cleveland Medical Center*Cleveland, United StatesTaking people
- Retina Consultants of Southern ColoradoColorado Springs, United StatesTaking people
- The Ohio State UniversityColumbus, United StatesTaking people
- Advanced ResearchCoral Springs, United StatesTaking people
- Retina Foundation of the SouthwestDallas, United StatesTaking people
- Texas Retina AssociatesDallas, United StatesTaking people
- University of Texas Southwestern Medical CenterDallas, United StatesTaking people
- Retina Specialists of Colorado - DenverDenver, United StatesTaking people
- Midwest Retina, IncDublin, United StatesTaking people
- Southwest Retina Research CenterDurango, United StatesTaking people
- Retina Vitreous Center - EdmondEdmond, United StatesTaking people
- The Retina PartnersEncino, United StatesNo longer taking part
- Erie Retinal Surgery & Erie Retina ResearchErie, United StatesTaking people
- Verum Research, LLCEugene, United StatesTaking people
- Retina Group of WashingtonFairfax, United StatesTaking people
- Retina Group of FloridaFort Lauderdale, United StatesTaking people
- National Ophthalmic Research InstituteFort Myers, United StatesNo longer taking part
- Star Retina PLLCFort Worth, United StatesTaking people
- Eye Medical Center of FresnoFresno, United StatesTaking people
- Retina Consultants of Orange CountyFullerton, United StatesNo longer taking part
- Retina Associates of MichiganGrand Blanc, United StatesTaking people
- Retina Consultants of CarolinaGreenville, United StatesTaking people
- Cumberland Valley Retina Consultants-OphthalmologyHagerstown, United StatesTaking people
- Mid Atlantic Retina SpecialistHagerstown, United StatesTaking people
- Graystone EyeHickory, United StatesTaking people
- ClearVista Clinical Research, Retina Center Tampa BayHudson, United StatesTaking people
- Salehi Retina Institute, dba Retina Associates of Southern CaliforniaHuntington Beach, United StatesTaking people
- University of California, IrvineIrvine, United StatesTaking people
- Florida Retina Institute, Jacksonville Perimeter Park- OphthalmologyJacksonville, United StatesTaking people
- Retina Consultants of TexasKaty, United StatesTaking people
- University of California San Diego, Jacobs Retina CenterLa Jolla, United StatesTaking people
- Charleston Neuroscience Institute LLCLadson, United StatesTaking people
- Florida Retina ConsultantsLakeland, United StatesTaking people
- Colorado Retina - LakewoodLakewood, United StatesTaking people
- University Retina and Macula Associates PC - LemontLemont, United StatesTaking people
- Retina Associates LLCLenexa, United StatesTaking people
- Retina Vitreous Surgeons of Central New York, PCLiverpool, United StatesTaking people
- South Coast Retina CenterLong Beach, United StatesTaking people
- Eye care Center of Northern Colorado doing business as Advanced Vision Research InstituteLongmont, United StatesTaking people
- Jules Stein Eye Institute in David Geffen School of Medicine at UCLALos Angeles, United StatesTaking people
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
- American Institute of ResearchLos Angeles, United StatesNo longer taking part
- University of LouisvilleLouisville, United StatesTaking people
- Piedmont Eye CenterLynchburg, United StatesTaking people
- Mississippi Retina AssociatesMadison, United StatesTaking people
- Retina Consultants - ManchesterManchester, United StatesTaking people
- Georgia Retina - MariettaMarietta, United StatesTaking people
- Valley Retina Institute P.A.McAllen, United StatesTaking people
- Retina Associate New OrleansMetairie, United StatesTaking people
- Ross Davis RetinaMetairie, United StatesTaking people
- Retinal Consultants Medical Group Inc ModestoModesto, United StatesTaking people
- West Virginia University Eye InstituteMorgantown, United StatesNo longer taking part
- Northern California Retina Vitreous Associates Medical Group INC.Mountain View, United StatesTaking people
- Charleston Neuroscience Institute, LLCMt. Pleasant, United StatesTaking people
- Bascom Palmer Eye InstituteNaples, United StatesTaking people
- Nashua Eye AssociatesNashua, United StatesTaking people
- Tennessee Retina, PCNashville, United StatesTaking people
- Vanderbilt Eye InstituteNashville, United StatesTaking people
- Ochsner HealthNew Orleans, United StatesTaking people
- New York Ear & Eye- East 85thNew York, United StatesTaking people
- Northwell Health- Manhattan, Ear, Eye and Throat Hospital- OphthalmologyNew York, United StatesTaking people
- Retina Associates of New York, Upper East SideNew York, United StatesTaking people
- MaculaCare, PLLCNew York, United StatesNo longer taking part
- Illinois Retina AssociatesOak Park, United StatesTaking people
- Florida Retina Institute - OrlandoOrlando, United StatesTaking people
- California Retina ConsultantsOxnard, United StatesTaking people
- Retina Care SpecialistsPalm Beach Gardens, United StatesTaking people
- Desert Retina ConsultantsPalm Desert, United StatesNo longer taking part
- California Eye Specialists Medical Group, Inc.Pasadena, United StatesTaking people
- Mid Atlantic Retina - Wills Eye HospitalPhiladelphia, United StatesTaking people
- Vision Research Solutions - the Eye InstitutePhiladelphia, United StatesTaking people
- Associated Retina ConsultantsPhoenix, United StatesTaking people
- Barnet Dulaney Perkins Eye CenterPhoenix, United StatesTaking people
- Retinal Research InstitutePhoenix, United StatesTaking people
- Eye Associates of PinellasPinellas Park, United StatesTaking people
- Red River Research Partners (Formerly AXIS Clinical)Plano, United StatesNo longer taking part
- EyeHealth NorthwestPortland, United StatesTaking people
- OHSU-Casey Eye Institute, Marquam Hill-OphthalmologyPortland, United StatesTaking people
- Retina Northwest, The Highlands BuildingPortland, United StatesTaking people
- Seeta Eye centerPoughkeepsie, United StatesTaking people
- Retina Consultants San DiegoPoway, United StatesTaking people
- Black Hills Regional Eye InstituteRapid City, United StatesTaking people
- California Eye Specialists Medical Group, Inc.Redlands, United StatesTaking people
- Virginia Eye InstituteRichmond, United StatesTaking people
- Retina Institute of VirginiaRichmond, United StatesNo longer taking part
- Kaiser Permanente Riverside Medical CenterRiverside, United StatesTaking people
- Austin Retina AssociatesRound Rock, United StatesTaking people
- Optic Eye CareRowland Heights, United StatesTaking people
- Retinal Consultants Medical Group (RCMG) - Greenback Lane Retina CenterSacramento, United StatesTaking people
- UC Davis Health Eye CenterSacramento, United StatesTaking people
- VRMG IncSacramento, United StatesTaking people
- Retina Associates Of Utah Retina SpecialistSalt Lake City, United StatesTaking people
- Rocky Mountain Retina ConsultantsSalt Lake City, United StatesTaking people
- Medical Center Ophthalmology AssociatesSan Antonio, United StatesTaking people
- Retina Associates of South TexasSan Antonio, United StatesTaking people
- Retina Consultants of TexasSan Antonio, United StatesTaking people
- Retina Consultants of Texas Brown Retina InstituteSan Antonio, United StatesTaking people
- West Coast Retina Medical Group, Inc.San Francisco, United StatesTaking people
- Orange County Retina Medical GroupSanta Ana, United StatesTaking people
- Retina Group of Florida, RAS-Sarasota Retina Center-OphthalmologySarasota, United StatesTaking people
- Retina Macula Institute of ArizonaScottsdale, United StatesTaking people
- Sewickley Eye GroupSewickley, United StatesTaking people
- Ophthalmology, LTD - Sioux FallsSioux Falls, United StatesTaking people
- Deep Blue Retina Clinical Research PLLCSouthaven, United StatesTaking people
- Retina Center of TexasSouthlake, United StatesTaking people
- Spokane Eye Clinical ResearchSpokane, United StatesTaking people
- Retina Partners of Northwest Arkansas, PLLCSpringdale, United StatesTaking people
- Cascade Medical Research Institute, LLCSpringfield, United StatesTaking people
- New England Retina Consultants, PCSpringfield, United StatesTaking people
- Springfield Clinic Main Campus EastSpringfield, United StatesTaking people
- Retina Research Institute, LLCSt Louis, United StatesTaking people
- Retina Vitreous Associates of Florida - Saint PetersburgSt. Petersburg, United StatesTaking people
- University of South Florida OphthalmologyTampa, United StatesTaking people
- New Jersey RetinaTeaneck, United StatesTaking people
- Retina Consultants TexasThe Woodlands, United StatesTaking people
- New Jersey RetinaToms River, United StatesTaking people
- Macula Retina Vitreous Research InstituteTorrance, United StatesTaking people
- Retina Associates of TuscanTucson, United StatesTaking people
- Tulsa Retina ConsultantsTulsa, United StatesTaking people
- Tyler Retina Research Institute- OphthalmologyTyler, United StatesTaking people
- North Carolina Retina AssociatesWake Forest, United StatesTaking people
- Massachusetts Eye Research and Surgery Institution (MERSI)Waltham, United StatesTaking people
- Retina Group of New EnglandWaterford, United StatesNo longer taking part
- Palmetto Retina CenterWest Columbia, United StatesTaking people
- Salt Lake Retina- OphthalmologyWest Jordan, United StatesTaking people
- Eye Assoc. of NE LA dba Haik Humble Eye CtrWest Monroe, United StatesTaking people
- Eye Associates of Northeast Louisiana dba Haik Humble Eye CenterWest Monroe, United StatesTaking people
- Piedmont Retina SpecialistWinston-Salem, United StatesTaking people
- Center for Retina and Macular DiseaseWinter Haven, United StatesTaking people
- Vitreo-Retinal Associates, PCWorcester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Regeneron Pharmaceuticals
- Trial code
- NCT06541704EU 2023-509547-27-00
- Record updated
- 5 November 2026
- Original description
This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead).Read full original descriptionShow less
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead).
The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug(s) * How much study drug(s) are in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Inclusion: Study eye with diagnosis of GA of the macula secondary to AMD as described in the protocol; Total GA area in the study eye measuring between ≥2.5 mm\^2 and ≤17.5 mm\^2 as described in the protocol; BCVA of 55 letters or better using ETDRS charts (20/80 Snellen equivalent) in the study eye as described in the protocol; Sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality fundus imaging in the study eye as described in the protocol; Willing and able to comply with clinic visits and study-related procedures, including completion of the full series of meningococcal vaccinations and pneumococcal vaccination required per protocol.
Exclusion: Prior or current Intravitreal (IVT) treatment of any kind for any indication in study eye or fellow eye, except approved or investigational IVT complement inhibitor therapy or anti-VEGF therapy, as long as last dose was ≥6 months prior to randomization; Prior intraocular surgery except cataract extraction or minimally invasive glaucoma surgery in study eye as long as date of these procedures was ≥3 months prior to randomization; History or current use of systemic complement inhibitor therapy within 6 months prior to randomization as described in the protocol; Use of chronic (>14 days) systemic corticosteroids (oral or parenteral, ≥20 mg oral prednisone or equivalent) within the previous 30 days prior to the first screening visit as described in the protocol; Current or prior use of systemic immunosuppressive therapy other than corticosteroids within 12 months prior to randomization or the likelihood of treatment with any such agent during the study inclusive of the screening period as described in the protocol; GA in either eye due to causes other than AMD, such as Stargardt disease, cone rod dystrophy or toxic maculopathies like hydroxychloroquine maculopathy; Comorbid progressive ocular condition (eg, diabetic retinopathy, macular edema, uncontrolled glaucoma, full thickness macular hole) in study eye that could affect central vision and confound study; Any ophthalmologic condition that reduces the clarity of the media and that, in the opinion of the investigator interferes with ophthalmologic examination of the study eye (e.g., advanced cataract or corneal abnormalities) as described in the protocol; Systemic Exclusion criteria; History of solid organ or bone marrow transplantation; Has a hemoglobin A1C ≥ 8.0% during screening as described in the protocol; NOTE: Other protocol-defined Inclusion/ Exclusion Criteria apply; History or current evidence of Macular Neovascularization (MNV) and/or exudation or Peripapillary Choroidal Neovascularization (PPCNV) in either eye as described in the protocol; Not meeting meningococcal or pneumococcal vaccination requirements as described in the protocol; Carrier of Neisseria meningitidis based on culture collected during screening.