Studying gut bacteria and ongoing belly pain in inflammatory bowel disease
Observes gut bacteria and ongoing belly pain in adults with inflammatory bowel disease.
Plain-language title generated from the registry record
Registry title: Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
Key facts
- Where
- Hamilton, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Crohn's disease or ulcerative colitis who have long-lasting moderate or severe belly pain even when the disease is calm or only mildly active.
- Age
- 18 to 70 years
- Sex
- All sexes can join
- Disease stage
- Crohn's disease or ulcerative colitis with past or current moderate or severe chronic belly pain that continues although the disease is in remission (no clear inflammation on CT or MRI, fecal calprotectin under 200 μg/g of stool) or only mildly inflamed on colonoscopy (SES-CD score 0-10 for Crohn's; Endoscopic Mayo score 0-1 for ulcerative colitis).
- Earlier treatment
- People cannot have taken antibiotics, antibacterial agents or probiotics now or in the last 8 weeks.
- Biomarker or test result
- Fecal calprotectin under 200 μg/g of stool.
Main reasons for not taking part
- Currently taking acid-reducing or antacid medicines
- Antibiotics, antibacterial agents or probiotics now or within the last 8 weeks
- Currently treating pain with opioids or NSAIDs (acetaminophen is allowed)
- Alcohol or drug abuse
- Another body-wide disease or lab results that the investigators see as a risk or that could disturb the data
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06548399, who can take part
Where in Canada
- McMaster UniversityHamilton, CanadaContact: Jumanah Alawfi, RDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- McMaster University
- Trial code
- NCT06548399
- Record updated
- 1 October 2026
- Original description
The purpose of this study is to investigate whether the gut bacteria in IBD patients cause ongoing abdominal pain, even when the disease is calm. Many inflammatory bowel disease (IBD) patients have this pain, regardless of whether their disease is active or not. This might be linked to an imbalance in gut bacteria. Certain IBD patients with persistent abdominal pain experience increased sensitivity in their gut due to bacteria producing LPC and LPA. Our goal is to explore the connection between bacterial LPC/LPA levels and symptoms in IBD patients with long-lasting abdominal pain. Additionally, we aim to pinpoint the specific bacteria responsible for producing LPC/LPA, which in turn causes chronic abdominal pain in these patients.Read full original descriptionShow less
Bacterial Production of LPC and LPA and Symptoms Generation in Inflammatory Bowel Disease Patients With Chronic Abdominal Pain: a Longitudinal Exploratory Study
The purpose of this study is to investigate whether the gut bacteria in IBD patients cause ongoing abdominal pain, even when the disease is calm. Many inflammatory bowel disease (IBD) patients have this pain, regardless of whether their disease is active or not. This might be linked to an imbalance in gut bacteria. Certain IBD patients with persistent abdominal pain experience increased sensitivity in their gut due to bacteria producing LPC and LPA. Our goal is to explore the connection between bacterial LPC/LPA levels and symptoms in IBD patients with long-lasting abdominal pain. Additionally, we aim to pinpoint the specific bacteria responsible for producing LPC/LPA, which in turn causes chronic abdominal pain in these patients.
Inclusion: 18 and 70 years of age; Crohn's disease diagnosis with history of past or current moderate or severe chronic abdominal pain that persist despite colitis being in remission (absence of overt inflammation on CT or MRI imaging, and baseline fecal calprotectin of less than 200 μg/g of stool), or in presence of mild inflammation defined by colonoscopy (Simple Endoscopic Score for Crohn's Disease score: 0-10),; Ulcerative colitis diagnosis with history of past or current moderate or severe chronic abdominal pain that persist despite colitis being in remission (absence of overt inflammation on CT or MRI imaging, and baseline fecal calprotectin less than 200 μg/g of stool) or in presence of mild inflammation defined by colonoscopy (Endoscopic Mayo score: 0-1).
Exclusion: Current acid anti-secretory and antacid medications; Current pain treatment with opioids or NSAIDs (acetaminophen is permitted); Alcohol or drug abuse; Concurrent systemic disease and/or laboratory abnormalities considered by investigators to be a risk or that could interfere with data collection; Antibiotics, antibacterial agents or probiotics, currently, or within the last 8 weeks.