Comparing One-Session and Multiple-Session Laser Treatment for Diabetic Eye Disease
Compares one laser treatment session with several sessions for proliferative diabetic retinopathy in adults.
Plain-language title generated from the registry record
Registry title: Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinopathy
Key facts
- Where
- Mölndal, SwedenSee the site
Where in Sweden
- Ögonmottagning Mölndal/SUMölndal, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vastra Gotaland Region
- Trial code
- NCT06549023
- Record updated
- 18 November 2025
- Original description
Proliferative diabetic retinopathy (PDR) is the leading cause for blindness in working-age adults. The current gold standard treatment for PDR is panretinal photocoagulation (PRP). In current clinical practice, both single-session and multiple-session PRP approaches are widely accepted and utilized. The purpose of this study is to compare the safety and effectiveness of single-session and multiple-session PRP.Read full original descriptionShow less
Single Session vs Multiple-Session Panretinal Photocoagulation With Navigated Laser in Proliferative Diabetic Retinopathy - The SMART-PRP Study
Proliferative diabetic retinopathy (PDR) is the leading cause for blindness in working-age adults. The current gold standard treatment for PDR is panretinal photocoagulation (PRP). In current clinical practice, both single-session and multiple-session PRP approaches are widely accepted and utilized. The purpose of this study is to compare the safety and effectiveness of single-session and multiple-session PRP.
Inclusion: Age > 18 years; Patients with type 1 or type 2 Diabetes Mellitus with newly diagnosed Proliferative Diabetic Retinopathy, PDR; Visual acuity ≥ 0.1 Snellen; CRT of less than 300 micrometer measured by OCT without cysts in the neuroretina; Clear media and adequately dilated pupil for PRP.
Exclusion: Intraocular surgery within the last 4 months or planned within the next 3 months; Previous or current center-involved diabetic macular edema (Ci-DME); Previous PRP, intravitreal treatment (IVT), or macular laser treatment in study eye; Treatment with medications known to risk macular edema; General medical condition making office laser treatment very difficult or impossible; Media opacity preventing adequate PRP.