Enrolling by invitationPhase 3

Continuation Protocol for Obstructive Sleep Apnea (OSA)

Key facts

Where: Abington, Albuquerque, Anaheim, Ann Arbor, Atlanta, Austin, Birmingham, Brandon, Canton, Cerritos, Chandler, Charleston, Chattanooga, Chesterfield, Chicago, Chula Vista, Cincinnati, Clearwater, Columbia, Cutler Bay, Dallas, Daytona Beach, Decatur, Denver, Eatontown, Fargo, Gastonia, Glen Burnie, Greenville, Hazelwood, Henderson, High Point, Houston, Huntersville, Huntsville, Kansas City, Lake Worth, Lathrup Village, Lehigh Acres, Little Rock, Los Alamitos, Los Angeles, Louisville, Memphis, Meridian, Mesa, Miami, Neptune City, New Bern, New Hyde Park, Newton, North Dartmouth, North Las Vegas, Novi, Ocala, Orlando, Phoenix, Pomona, Portland, Riverside, Rock Hill, Rockville, San Antonio, San Diego, San Ramon, Santa Ana, South Ogden, Springfield, St Louis, Sterling Heights, Suwanee, Tampa, Tempe, Tucson, Tuscaloosa, Valdosta, Vienna, West Covina, West Palm Beach, Wilmington, Winter Park, and Wyomissing, United StatesSee the 93 sites
Phase: Phase 3

Where in United States

Abington Neurological AssociatesAbington, United StatesNo longer taking part
Maimonides Sleep Arts & SciencesAlbuquerque, United StatesNo longer taking part
Orange County Research InstituteAnaheim, United StatesNo longer taking part
University of Michigan Clinical Research UnitAnn Arbor, United StatesNo longer taking part
Atlanta Center for Medical ResearchAtlanta, United StatesNo longer taking part
NeuroTrials Research IncAtlanta, United StatesNo longer taking part
FutureSearch Trials of NeurologyAustin, United StatesNo longer taking part
Sleep Disorders Center of AmericaBirmingham, United StatesNo longer taking part
Meris Clinical ResearchBrandon, United StatesNo longer taking part
Teradan Clinical TrialsBrandon, United StatesNo longer taking part
NeuroScience Research Center LLCCanton, United StatesNo longer taking part
Core Healthcare GroupCerritos, United StatesNo longer taking part
Chandler Clinical TrialsChandler, United StatesNo longer taking part
Lowcountry Lung and Critical Care, PACharleston, United StatesNo longer taking part
Chattanooga Research & MedicineChattanooga, United StatesNo longer taking part
Sleep Medicine and Research Center, St. Luke's HospitalChesterfield, United StatesNo longer taking part
Chicago Research Center Inc.Chicago, United StatesNo longer taking part
Exalt Clinical Research IncChula Vista, United StatesNo longer taking part
CTI Clinical Research CenterCincinnati, United StatesNo longer taking part
Intrepid Research, LLCCincinnati, United StatesNo longer taking part
St Francis Medical InstituteClearwater, United StatesNo longer taking part
Centennial Medical Group Research DepartmentColumbia, United StatesNo longer taking part
Nouvelle Clinical ResearchCutler Bay, United StatesNo longer taking part
FutureSearch Trials of DallasDallas, United StatesNo longer taking part
Arrow Clinical TrialsDaytona Beach, United StatesNo longer taking part
CenExel iResearch, LLCDecatur, United StatesNo longer taking part
Mountain View Clinical Research, IncDenver, United StatesNo longer taking part
Research Carolina EliteDenver, United StatesNo longer taking part
Clinilabs Drug Development CorporationEatontown, United StatesNo longer taking part
Lillestol ResearchFargo, United StatesNo longer taking part
Clinical Research of GastoniaGastonia, United StatesNo longer taking part
Sleep Disorders Centers of the Mid-AtlanticGlen Burnie, United StatesNo longer taking part
Tribe Clinical Research LLCGreenville, United StatesNo longer taking part
Velocity Clinical Research - GreenvilleGreenville, United StatesNo longer taking part
Healthcare Research NetworkHazelwood, United StatesNo longer taking part
Henderson Clinical TrialsHenderson, United StatesNo longer taking part
Peters Medical Research, LLCHigh Point, United StatesNo longer taking part
Houston Clinical Research AssociatesHouston, United StatesNo longer taking part
Memorial Hermann VillageHouston, United StatesNo longer taking part
Advanced Respiratory and Sleep MedicineHuntersville, United StatesNo longer taking part
Huntsville Research InstituteHuntsville, United StatesNo longer taking part
University of Kansas Medical CenterKansas City, United StatesNo longer taking part
Canvas Clinical ResearchLake Worth, United StatesNo longer taking part
Revive Research Institute, Inc.Lathrup Village, United StatesNo longer taking part
Florida Lung & Sleep AssociatesLehigh Acres, United StatesNo longer taking part
Preferred Research Partners, IncLittle Rock, United StatesNo longer taking part
Collaborative Neuroscience Research, LLCLos Alamitos, United StatesNo longer taking part
Santa Monica Clinical TrialsLos Angeles, United StatesNo longer taking part
Advanced ENT and AllergyLouisville, United StatesNo longer taking part
Clinical Neuroscience Solutions, Inc.Memphis, United StatesNo longer taking part
St. Luke's Idaho Pulmonary Associates - Meridian ClinicMeridian, United StatesNo longer taking part
Desert Clinical Reserach, LLC/CCT ResearchMesa, United StatesNo longer taking part
Advanced Medical Research InstituteMiami, United StatesNo longer taking part
Flourish ResearchMiami, United StatesNo longer taking part
Ivetmar Medical Group, LLCMiami, United StatesNo longer taking part
PharmaDev Clinical Research Institute, LLCMiami, United StatesNo longer taking part
Sleep DynamicsNeptune City, United StatesNo longer taking part
Coastal Carolina Health Care, P.A. Pulmonary and Sleep MedicineNew Bern, United StatesNo longer taking part
Northwell HealthNew Hyde Park, United StatesNo longer taking part
Neurocare, Inc.Newton, United StatesNo longer taking part
Infinity Medical ResearchNorth Dartmouth, United StatesNo longer taking part
Las Vegas Clinical Trials, LLCNorth Las Vegas, United StatesNo longer taking part
Henry Ford Medical Center-ColumbusNovi, United StatesNo longer taking part
Renstar Medical ResearchOcala, United StatesNo longer taking part
Clinical Neuroscience Solutions, Inc.Orlando, United StatesNo longer taking part
Foothills Research Center Cct ResearchPhoenix, United StatesNo longer taking part
Empire Clinical ResearchPomona, United StatesNo longer taking part
Northwest Research CenterPortland, United StatesNo longer taking part
Probe Clinical Research CorporationRiverside, United StatesNo longer taking part
Onsite Clinical Solutions, LLCRock Hill, United StatesNo longer taking part
Velocity Clinical ResearchRockville, United StatesNo longer taking part
Element Research GroupSan Antonio, United StatesNo longer taking part
Sleep Therapy and Research CenterSan Antonio, United StatesNo longer taking part
Pacific Research NetworkSan Diego, United StatesNo longer taking part
TriValley Sleep CenterSan Ramon, United StatesNo longer taking part
SDS Clinical Trials, Inc.Santa Ana, United StatesNo longer taking part
South Ogden Family Medicine/CCT ResearchSouth Ogden, United StatesNo longer taking part
Baystate Clinical Trials UnitSpringfield, United StatesNo longer taking part
Clayton Sleep Institute, LLCSt Louis, United StatesNo longer taking part
Clinical Neurophysiology Services PCSterling Heights, United StatesNo longer taking part
Georgia Neurology and Sleep Medicine AssociatesSuwanee, United StatesNo longer taking part
JSV Clinical Research Study IncTampa, United StatesNo longer taking part
Fiel Family and Sports Medicine/CCT ResearchTempe, United StatesNo longer taking part
Noble Clinical ResearchTucson, United StatesNo longer taking part
The University of Alabama/Institute for Rural Health ResearchTuscaloosa, United StatesNo longer taking part
Medster ResearchValdosta, United StatesNo longer taking part
Sleep Disorder Center of the Mid-AtlanticVienna, United StatesNo longer taking part
Providere Research IncWest Covina, United StatesNo longer taking part
Palm Beach Research CenterWest Palm Beach, United StatesNo longer taking part
AccellacareWilmington, United StatesNo longer taking part
Central Florida Pediatric Sleep Disorders d/b/a Florida Pediatric Institute, LLCWinter Park, United StatesNo longer taking part
Clinical Site Partners, LLC dba Flourish ResearchWinter Park, United StatesNo longer taking part
Respiratory SpecialistsWyomissing, United StatesNo longer taking part

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it: Apnimed
Trial code: NCT06566820
Record updated: 13 May 2025
Original description: The combination drug composed of aroxybutynin and atomoxetine, designated AD109, is being developed by Apnimed for the treatment of obstructive sleep apnea (OSA). The present study is a Phase 3 open label continuation protocol enrolling qualifying participants who completed one of the parent Phase 3 double-blind placebo-controlled studies, APC-APN-304 or APC-APN-305.Read full original descriptionShow less
A Phase 3 Open Label Continuation Protocol of a Fixed Dose Combination of Aroxybutynin and Atomoxetine (AD109) in Obstructive Sleep Apnea
The combination drug composed of aroxybutynin and atomoxetine, designated AD109, is being developed by Apnimed for the treatment of obstructive sleep apnea (OSA). The present study is a Phase 3 open label continuation protocol enrolling qualifying participants who completed one of the parent Phase 3 double-blind placebo-controlled studies, APC-APN-304 or APC-APN-305.
Inclusion: Completion of APC-APN-304 without permanent discontinuation of IMP; Completion of APC-APN-305 without permanent discontinuation of IMP.
Exclusion: Participants are excluded from the study if participation would be considered unsafe by the investigator based on concomitant therapies; Participants are excluded from the study if participation would be considered unsafe by the investigator based on the individual's current status.
ClinicalTrials.gov NCT06566820