Choosing Depression Treatment by Patient Profile Compared With Usual Clinician Choice
Compares profile-guided treatment selection with usual selection in adults with major depressive disorder.
Plain-language title generated from the registry record
Registry title: Precision Care for Major Depressive Disorder
Key facts
- Where
- San Francisco, United StatesSee the site
- Phase
- Phase 4
Where in United States
- Nancy Friend Pritzker Psychiatry Building, University of California, San FranciscoSan Francisco, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, San Francisco
- Trial code
- NCT06580041
- Record updated
- 5 September 2025
- Original description
This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for depression.Read full original descriptionShow less
Precision Care for Major Depressive Disorder
This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for depression.
Inclusion: Participant is able to provide informed consent; English speaker; 18 years of age or older at time of consent; Meets DSM-5 criteria for Major Depressive Disorder; The subject meets eligibility criteria for at least one study phenotype as determined by assessments, imaging and/or clinical judgment; PHQ-8 score at baseline of >= 10; Scheduled for or completed intake in UCSF outpatient psychiatry.
Exclusion: Unstable or untreated medical or psychiatric condition based on clinical assessment by investigator(s); In the Investigators' opinion, the subject is not capable of adhering to the protocol requirements, or the subject has a history of poor or suspected poor compliance in clinical research studies, or the subject has a history of poor or suspected poor compliance to antidepressant medication or that study participation is not in their best interest (e.g., different treatment is indicated given their clinical presentation); Significant risk of suicidal or violent behavior as determined by clinical judgement; Pregnant or breastfeeding or planning to become pregnant during the study.