Tests breathing gas exposures for brain fog in long COVID
Tests low-oxygen and high-carbon-dioxide breathing exposures in adults with long COVID.
Plain-language title generated from the registry record
Registry title: Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
Key facts
- Where
- Scottsdale, United StatesSee the site
Where in United States
- Mayo Clinic in ArizonaScottsdale, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06614309
- Record updated
- 5 June 2026
- Original description
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.Read full original descriptionShow less
Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
Inclusion: English speaking; Diagnosis of Long COVID.
Exclusion: Any history of:; Coronary artery dissection or aortic dissection; Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease); Cerebrovascular disease or stroke; Aneurysm; If currently has:; Moderate-severe chronic obstructive pulmonary disease; Uncontrolled moderate-severe asthma; Moderate-severe bronchiectasis; Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen; A necessity to use supplemental oxygen, for any reason; New or worsening symptoms (decompensation) of heart failure; Right heart disease due to chronic pulmonary disease/sleep apnea; Uncontrolled myocardial ischemia or angina; Uncontrolled heart arrhythmias; Heart or lung infection (e.g. myocarditis or pericarditis); Left main coronary artery stenosis; Moderate-severe aortic stenosis; Pulmonary embolism, pulmonary infarction, or other blood clots; Severe respiratory disease; Chronic kidney disease; Chronic liver disease; Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy; BMI >40; Study staff unable to obtain adequate signal for cerebral blood flow.