Treating Depression in Mothers of Children With Asthma
Tests a talk-based depression treatment for mothers of children with asthma.
Plain-language title generated from the registry record
Registry title: The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic
Key facts
- Where
- Washington D.C., United StatesSee the site
Where in United States
- Children's National HospitalWashington D.C., United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Children's National Research Institute
- Trial code
- NCT06623981
- Record updated
- 24 February 2026
- Original description
The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children under the age of 18 in an urban pediatric asthma clinic. Researchers will compare Enhanced IPT-B and supplemented usual care (brief care coordination). The main questions the trial aims to answer are:Read full original descriptionShow less
Testing the Effectiveness and Implementation of an Evidence-Based Maternal Depression Treatment in an Urban Pediatric Asthma Clinic
The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children under the age of 18 in an urban pediatric asthma clinic. Researchers will compare Enhanced IPT-B and supplemented usual care (brief care coordination). The main questions the trial aims to answer are:
1. Does Enhanced IPT-B decrease maternal depressive symptoms? 2. Does Enhanced IPT-B improve child asthma management and health outcomes (exacerbations, symptoms, control)? 3. What are the preliminary implementation outcomes of delivering Enhanced IPT-B in an urban pediatric asthma clinic?
Inclusion: Maternal:; Primary caregiver of the child with asthma seen at the community-based asthma clinic; Female (self-identified); Black (self-identified); ≥ 18 years of age; English-speaking; PHQ-9 ≥ 8 during standardized screening at the child with asthma's clinic visit; Child:; <18 years old for the duration of the 6-month study period; Publicly insured; Physician-diagnosed persistent asthma.
Exclusion: Bipolar disorder or mania; Significant medical co-morbidity (e.g., disorders of the cardiorespiratory system, significant developmental delay, diabetes, seizure disorder, and sickle cell disease); Maternal:; Acutely suicidal (high risk on the C-SSRS at child's asthma clinic visit); Schizophrenia; Current substance abuse/dependence; Current serious physical intimate partner violence (IPV); Lack of capacity to meaningfully participate in study procedures, as assessed by study staff during screening; Child:; Enrolled in another intervention with a behavioral component and/or novel asthma therapeutics.