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Program to help older adults with hypothyroidism cut back thyroid medicine

Tests a program to lower thyroid hormone doses in older adults.

Key facts

Who runs it
University of Michigan
Where
Ann Arbor, Detroit, and San Francisco, United StatesSee the 3 sites
Trial code
Registry title
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Status
Recruiting
People taking part
900 people, planned
Started
2 Dec 2024
Expected to end
31 Aug 2028
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • D-THIO (Deprescribing Thyroid Hormone In Older Adults)
  • Enhanced usual care
Record updated
4 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 65 years and older who take thyroid hormone and may be getting too much, or taking it for a reason that is not appropriate. Their doctors and other prescribers also take part.

Age
65 years and older
Sex
All sexes
Disease stage
People on thyroid hormone therapy who are overtreated or who take it for an inappropriate reason.
Earlier treatment
Must be on thyroid hormone therapy now.
Biomarker or test result
Blood TSH (thyroid-stimulating hormone) below 0.5 mIU/L, or thyroid hormone taken for an inappropriate reason.

Main reasons for not taking part

  • Thyroid cancer
  • Secondary hypothyroidism (low thyroid caused by a pituitary or brain problem)
  • Whole thyroid gland removed by surgery in the past
  • Hospital stay in the past 3 months
  • Memory or thinking problems, or not speaking English

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • age 65 years and older
  • on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) <0.5 mIU/L or are on thyroid hormone therapy for an inappropriate indication
  • English speaking
  • without cognitive impairment

Who cannot take part

  • Patients with a diagnosis of thyroid cancer, secondary hypothyroidism, history of total thyroidectomy or hospitalization in the past 3 months will be excluded; Provider eligibility:; Inclusion: Primary care physicians, endocrinologists, geriatricians, and Advanced Practice Providers (APPs) who practice at University of Michigan, Henry Ford Health System or University of California San Fransico (UCSF) and who prescribe thyroid hormone for eligible patients identified above will be eligible for study participation; Exclusion: Providers who don't prescribe thyroid hormone

Other criteria

  • Patient Eligibility:

Where in United States

  • University of MichiganAnn Arbor, United StatesContact: Brittany GayTaking people
  • Henry Ford Health SystemDetroit, United StatesContact: Araceli AmbersTaking people
  • University of California San FranciscoSan Francisco, United StatesContact: Zoe ChengTaking people

About the trial

What the trial wants to find out

The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or discontinuation) in older adults with thyroid hormone overtreatment and/or misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring.

The 2 groups in the trial

  • D-THIO (Deprescribing Thyroid Hormone In Older Adults)Treatment being tested

    D-THIO is an innovative adapted multilevel intervention. Providers in the intervention arm will receive: 1) an introductory letter, and 2) the D-THIO pharmaceutical opinion via EMR-compatible correspondence. After randomization of their treating providers, patients in the intervention arm will receive a study packet including: 1) introductory letter, and 2) the D-THIO patient brochure (educational EMPOWER brochure).

  • Enhanced usual careExisting treatment, for comparison

    This arm will receive enhanced usual care. Providers in the control arm will receive: 1) an introductory letter signed by the PI and site-PIs, and 2) the ATA hypothyroidism pocket card via EMR. Patients in the control arm will receive a study packet including: 1) introductory letter, and 2) the ATA patient brochure.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Plain-language title
Program to help older adults with hypothyroidism cut back thyroid medicineGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
4 September 2026