Testing exercise and heart rhythm ablation in heart failure with atrial fibrillation
Tests exercise training with ablation in adults with heart failure and atrial fibrillation.
Plain-language title generated from the registry record
Registry title: AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Key facts
- Where
- Munich, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT06650995, who can take part
Where in Germany
- Department of Medicine, Division of Prevention and Sports Medicine TU MunichMunich, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Technical University of Munich
- Trial code
- NCT06650995
- Record updated
- 18 September 2026
- Original description
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations.Read full original descriptionShow less
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations.
Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
Inclusion: Diagnosed heart failure with preserved ejection fraction; Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion).
Exclusion: Prior ablation therapy; Clinically unstable coronary artery disease or acute coronary syndrome; Precapillary pulmonary hypertension at rest; High-degree valve insufficiency or stenosis (greater than grade 1 at rest); Left ventricular ejection fraction <50%; Paroxysmal, long-persistent or permanent atrial fibrillation; Physical and/or mental inability to perform exercise testing; Intracardiac shunts.