Tests heart failure networks for people recently hospitalized with worsening heart failure
Compares heart failure network care with usual care in adults newly admitted with heart failure.
Plain-language title generated from the registry record
Registry title: Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study
Key facts
- Where
- Leipzig, GermanySee the site
Where in Germany
- University Hospital LeipzigLeipzig, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Leipzig
- Trial code
- NCT06656832
- Record updated
- 6 May 2026
- Original description
PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany. For the randomised part, 750 patients will be randomized to care within a heart failure network or usual care. The primary endpoint of the randomized trial is change in NT-proBNP from baseline to 6 months of follow-up.Read full original descriptionShow less
Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study
PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany. For the randomised part, 750 patients will be randomized to care within a heart failure network or usual care. The primary endpoint of the randomized trial is change in NT-proBNP from baseline to 6 months of follow-up.
All patients (randomized or not) will be followed for two years.
Inclusion: Patients admitted to the participating study centres with acute decompensated heart failure (ADHF), defined as clinical signs and/or symptoms of heart failure; objective structural cardiac abnormalitites according to the ESC criteria.
Exclusion: any condition interfering with the informed consent process; Age <18 years; pregnancy; patients placed in an institution by official or court order.