Tests orforglipron for weight management in children with obesity or overweight
Tests orforglipron against placebo in children aged 6 to 17 with obesity or overweight.
Plain-language title generated from the registry record
Registry title: A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Key facts
- Where
- Atlanta, Austin, Baltimore, Boston, Buffalo, Chapel Hill, Charleston, Chicago, Cleveland, Colorado Springs, Columbus, Corpus Christi, Durham, Grand Rapids, Gulfport, Houston, Indianapolis, Lafayette, Loma Linda, Los Angeles, Louisville, Minneapolis, Morehead City, Nashville, New Haven, Oklahoma City, Omaha, Orange, Orlando, Oxnard, Pittsburgh, Richmond, Rochester, Saint Paul, Seattle, St Louis, St. Petersburg, Stamford, Tacoma, Tomball, Tucson, and West Jordan, United StatesSee the 50 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 17 years old?
Source: NCT06672549, who can take part
Where in United States
- Children's Healthcare of Atlanta Center for Advanced PediatricsAtlanta, United StatesNot yet recruiting
- Dell Children's Medical Center - PINAustin, United StatesNot yet recruiting
- Johns Hopkins Children's CenterBaltimore, United StatesNot yet recruiting
- Boston Children's HospitalBoston, United StatesNot yet recruiting
- UBMD PediatricsBuffalo, United StatesNot yet recruiting
- UNC Children's HospitalChapel Hill, United StatesNot yet recruiting
- Coastal Pediatric AssociatesCharleston, United StatesNot yet recruiting
- Medical University of South Carolina Children HospitalCharleston, United StatesNot yet recruiting
- Ann and Robert Lurie Children's Hospital of ChicagoChicago, United StatesNot yet recruiting
- University of Illinois at ChicagoChicago, United StatesNot yet recruiting
- Cleveland ClinicCleveland, United StatesNot yet recruiting
- Children's Hospital ColoradoColorado Springs, United StatesNot yet recruiting
- Nationwide Children's HospitalColumbus, United StatesNot yet recruiting
- Driscoll Children's HospitalCorpus Christi, United StatesNot yet recruiting
- Duke Children's Primary CareDurham, United StatesNot yet recruiting
- Helen Devos Childrens' Hospital - PINGrand Rapids, United StatesNot yet recruiting
- Dynamed Clinical Research, LP d/b/a DM Clinical ResearchGulfport, United StatesNot yet recruiting
- Dynamed Clinical Research LP d/b/a DM Clinical ResearchHouston, United StatesNot yet recruiting
- La Providence Pediatrics Clinic - Chemidox Clinical TrialsHouston, United StatesNot yet recruiting
- McGovern Medical SchoolHouston, United StatesNot yet recruiting
- Texas Childrens HospitalHouston, United StatesNot yet recruiting
- Riley Hospital for ChildrenIndianapolis, United StatesNot yet recruiting
- Velocity Clinical ResearchLafayette, United StatesNot yet recruiting
- Loma Linda University School of MedicineLoma Linda, United StatesNot yet recruiting
- Childrens Hospital of Los AngelesLos Angeles, United StatesNot yet recruiting
- UCLA Mattel Children's HospitalLos Angeles, United StatesNot yet recruiting
- Norton Children's EndocrinologyLouisville, United StatesNot yet recruiting
- University of Minnesota/Masonic Children's HospitalMinneapolis, United StatesNot yet recruiting
- Lucas Research, Inc.Morehead City, United StatesTaking people
- Vanderbilt Health One Hundred OaksNashville, United StatesNot yet recruiting
- Yale School of Medicine - Yale Diabetes Center (YDC)) TrialsNew Haven, United StatesNot yet recruiting
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesNot yet recruiting
- Omaha Childrens HospitalOmaha, United StatesNot yet recruiting
- Velocity Clinical ResearchOmaha, United StatesNot yet recruiting
- Children's Hospital of Orange County - OrangeOrange, United StatesNot yet recruiting
- Florida Hospital- Center for Pediatric ResearchOrlando, United StatesNot yet recruiting
- Nemours Children's HealthOrlando, United StatesNot yet recruiting
- Carey Chronis MD Pediatric, Infant and Adolescent MedicineOxnard, United StatesNot yet recruiting
- UPMC Children's Hospital of PittsburghPittsburgh, United StatesNot yet recruiting
- VCU Health - Center for Endocrinology Diabetes and MetabolismRichmond, United StatesNot yet recruiting
- Mayo Clinic - PINRochester, United StatesNot yet recruiting
- Children's Minnesota Pediatric Endocrinology Clinic & McNeeley Diabetes CenterSaint Paul, United StatesNot yet recruiting
- Seattle Children's Research Institute - Hughes Building - PINSeattle, United StatesNot yet recruiting
- Sundance Clinical ResearchSt Louis, United StatesNot yet recruiting
- All Childrens HospitalSt. Petersburg, United StatesNot yet recruiting
- Stamford Therapeutics ConsortiumStamford, United StatesNot yet recruiting
- MultiCare Health System - Mary Bridge Children's Health CenterTacoma, United StatesNot yet recruiting
- Martin Diagnostic ClinicTomball, United StatesNot yet recruiting
- University of ArizonaTucson, United StatesNot yet recruiting
- Velocity Clinical Research, Salt Lake CityWest Jordan, United StatesNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT06672549
- Record updated
- 4 November 2026
- Original description
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.Read full original descriptionShow less
A Master Protocol for a Randomized, Controlled, Clinical Platform Trial to Investigate the Efficacy and Safety of Interventions for Chronic Weight Management in Pediatric Participants With Obesity or Overweight
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.
Inclusion: Have a history of at least 1 unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification program (diet and exercise counseling for at least 3 months) prior to screening; Obesity as defined by BMI equal to or above the 95th percentile for age and sex (on age- and gender-specific growth chart [CDC-NCHS, 2022]); OR; Applies to participant age between 12 and <18 years old. Overweight as defined by BMI equal to or above the 85th percentile but less than the 95th percentile for age and sex, on age- and sex-specific growth chart (CDC-NCHS, 2022), and at least 1 weight-related comorbidity,; hypertension; type 2 diabetes (T2D); prediabetes; dyslipidemia; obstructive sleep apnea; metabolic dysfunction-associated steatohepatitis (MASH) or metabolic dysfunction-associated steatotic liver disease (MASLD).
Exclusion: Have undergone or plan to undergo weight reduction procedure during the study, such as, but not limited to:; gastric bypass; sleeve gastrectomy; restrictive bariatric surgery, such as Lap-Band® gastric banding, or; any other procedure intended to result in weight reduction; Have a self-reported, or by parent or legal guardian where applicable, decrease in body weight greater than 5 kg (11 lbs) within 90 days before screening irrespective of medical records; Have a diagnosis that is a secondary cause of obesity or have a history of abrupt onset of obesity suggesting a secondary cause, such as hypothalamic, monogenetic, syndromic, or endocrine causes; Have type 1 diabetes or history of ketoacidosis, or hyperosmolar state; Have a family or personal history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia Syndrome Type 2; Have HbA1c >9.0% (75 mmol/mol) as measured by central laboratory at screening.