Brisk walking after a late insulin dose in type 1 diabetes
Tests a 15-minute walk after late mealtime insulin in young adults with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose
Key facts
- Where
- Montreal, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 24 years old?
Source: NCT06686329, who can take part
Where in Canada
- Institut de Recherches Cliniques de MontrealMontreal, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jane Yardley
- Trial code
- NCT06686329
- Record updated
- 12 March 2026
- Original description
People living with type 1 diabetes (PwT1D) are recommended to administer insulin 10-15 minutes before meal consumption (pre-bolus), to account for the delay in the glucose lowering action associated with subcutaneously administered insulin. Due to the demands of day-to-day life, pre-bolusing is not always possible or may be forgotten. With continuous glucose monitors (CGMs), PwT1D may be alerted to this missed insulin dose by a CGM alert, including rapidly rising glucose (change >2.5mmol/L/15min) or hyperglycemia (>10.0 mmol/L), and deliver a mistimed (post-prandial) dose in response to CGM alert.Read full original descriptionShow less
Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose: The MISSED DOSE Study
People living with type 1 diabetes (PwT1D) are recommended to administer insulin 10-15 minutes before meal consumption (pre-bolus), to account for the delay in the glucose lowering action associated with subcutaneously administered insulin. Due to the demands of day-to-day life, pre-bolusing is not always possible or may be forgotten. With continuous glucose monitors (CGMs), PwT1D may be alerted to this missed insulin dose by a CGM alert, including rapidly rising glucose (change >2.5mmol/L/15min) or hyperglycemia (>10.0 mmol/L), and deliver a mistimed (post-prandial) dose in response to CGM alert.
This study was designed to determine the effect of combining a post-prandial/mistimed insulin dose with 15 minutes of brisk walking. It is expected that walking will help to minimize or prevent hyperglycemia after a mistimed bolus insulin dose, as well as blunt the rise in glucose following a mistimed insulin dose.
Inclusion: Adults aged 18-24 years; Type 1 diabetes diagnostic for at least two years; Estimated glycated hemoglobin or glucose management indicator obtained from the past 30 days of CGM data of < 9.9%; Use a Dexcom G7 CGM in routine care.
Exclusion: Having a condition that could render exercise harmful; Having significant renal disease (e.g., eGRF < 30 ml/min); Currently taking other medications (other than insulin) that may alter glucose metabolism (e.g., non-insulin antihyperglycemic drugs such as sglt2-inhibitors, corticosteroids), unless dosages thereof have been stable for more than three months; Changes in insulin management strategy within the past 2 months; Diagnosis of gastroparesis; Intolerance to gluten and lactose; Inability to provide informed consent due to cognitive deficit; For women, being pregnant or breastfeeding.