Testing Pain Responses in People with Huntington's Disease
Tests pain signals and expressions in 20 adults with Huntington's disease.
Key facts
- Who runs it
- Leiden University Medical Center
- Where
- Leiden, NetherlandsSee the site
- Trial code
- Registry title
- Huntington's Disease and Pain
- Status
- Not yet recruiting
- People taking part
- 20 people, planned
- Started
- Jan 2025
- Planned end
- Jul 2026
- Type of study
- Observational, 2 groups
- Treatments tested
- Facial expression block
- Conditioned pain modulation block
- Pain facilitation block
- Record updated
- 18 November 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with genetically confirmed Huntington's disease in an early or middle stage. It tests three pain test batteries in 20 patients.
- Age
- 21 years and older
- Sex
- All sexes can join.
- Disease stage
- Adult-onset Huntington's disease, confirmed by genetic test and clinical exam: stage 1 (10 people) and stages 2 - 3 (10 people). Late-stage disease (UDHRS-TFC score <3) is not included.
- Biomarker or test result
- CAG repeats ≥ 36 (DCL of 4).
Main reasons for not taking part
- Juvenile or pediatric Huntington's disease (onset before age 21)
- Late stage of the disease (UDHRS-TFC score <3)
- Nerve disease or other problem that disturbs the sense of touch and pain and could affect the pain tests
- Drug, alcohol or medication (ab)use in the past year or now that could seriously interfere with the study
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Genetically and clinically confirmed Adult-onset HD patients (≥ 21 years, CAG repeats ≥ 36; DCL of 4)
- Good general health apart from having HD. Note: Patients with chronic illness (e.g. hypertension) will be eligible if the illness is stable and well-controlled according to the investigator that will not impact the primary objectives of the study
- Able to give written informed consent
Who cannot take part
- Patients in the late stage of the disease (UDHRS-TFC score <3)
- Have medical, psychiatric, or other conditions (other than HD) that, according to the investigator, may compromise the patient's ability to understand the patient information sheet, to give informed consent, to comply with all study requirements, or to perform study assessments
- Have a history of (in the past year) or current (ab)use of any drug, alcohol or medication that, in the opinion of the investigator, may seriously interfere with the primary objectives of the study
- Juvenile and Pediatric Huntington's Disease (age at onset <21 years)
- The presence of a sensorimotor neuropathy or any another disturbance significantly disturbing the somatosensory systems, based on medical history and/or clinical examination, that can interfere with the pain test battery
- Women who are pregnant or breastfeeding
Where in Netherlands
- Leiden University Medical CenterLeiden, NetherlandsContact: Gregory Sprenger, MscNo longer taking part
About the trial
What the trial wants to find out
The primary objective of this pilot study is to assess the feasibility of three internationally agreed pain test batteries in patients with Huntington Disease. The pain test batteries are developed to collect data about the facial expression of pain, body movements and vocalization of (non-) painful stimuli, and to collect data for testing the pain inhibition and facilitation. The study population will include 20 patients with genetically confirmed, adult-onset HD, in stage 1 (n=10) and stages 2 - 3 of HD (n = 10).
The 2 groups in the trial
- Adult-onset HD stage 1
The adult-onset HD stage 1 group (total function capacity 11-13) include 10 participants. The subjects will be undergo three different pain test batteries .
Treatment: Facial expression block, Conditioned pain modulation block, and Pain facilitation block
- Adult-onset HD stage 2-3
The adult-onset HD stage 2-3 group (total function capacity 3-10) include 10 participants. The subjects will be undergo three different pain test batteries .
Treatment: Facial expression block, Conditioned pain modulation block, and Pain facilitation block
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Pain Processing and Pain Assessment in Huntington's Disease a Pilot Study
- Plain-language title
- Testing Pain Responses in People with Huntington's DiseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Publications
- Record updated
- 18 November 2024