Testing blood pressure targets in people on in-centre hemodialysis
Tests whether lower or higher blood pressure targets suit adults receiving dialysis at clinics.
Plain-language title generated from the registry record
Registry title: Feasibility of a Randomized Cluster Trial for Blood Pressure Targets in In-centre Hemodialysis Units
Key facts
- Where
- Winnipeg, CanadaSee the site
Where in Canada
- University of ManitobaWinnipeg, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Manitoba
- Trial code
- NCT06695611
- Record updated
- 19 November 2024
- Original description
High blood pressure in people receiving hemodialysis is known to contribute to heart disease and heart-related death from strokes, heart failure, left ventricular hypertrophy (which is a thickening of the heart wall that makes it difficult for the heart to pump blood) and arrythmias (an irregular or abnormal heartbeat). In comparison, low blood pressure can lead to cramps, myocardial stunning, and cerebrovascular ischemia. However, despite, blood pressure management being an important component of hemodialysis care, the "best" blood pressure target for people on hemodialysis is unknown.Read full original descriptionShow less
Evaluating the Feasibility of a Randomized Cluster Trial for Blood Pressure Targets in In-centre Hemodialysis Units (BP in HD Pilot Trial)
High blood pressure in people receiving hemodialysis is known to contribute to heart disease and heart-related death from strokes, heart failure, left ventricular hypertrophy (which is a thickening of the heart wall that makes it difficult for the heart to pump blood) and arrythmias (an irregular or abnormal heartbeat). In comparison, low blood pressure can lead to cramps, myocardial stunning, and cerebrovascular ischemia. However, despite, blood pressure management being an important component of hemodialysis care, the "best" blood pressure target for people on hemodialysis is unknown.
Finding the "right" blood pressure to target can have a major impact on patient lives. We are proposing a large, pragmatic, cluster randomized trial targeting a lower versus higher blood pressure target in in-centre hemodialysis units in Canada. Our initial steps towards this bigger trial are to run a smaller trial including 4 units, to evaluate whether it is feasible to conduct a larger trial. Our ultimate goal is to deliver the definitive randomized trial for blood pressure targets in the hemodialysis population.
Inclusion: Age > 18 years old; Undergoing in-centre hemodialysis at least twice weekly; > 90 days since initiation of dialysis.
Exclusion: Anticipated living donor kidney transplant within 3 months; Participation in another intervention study that may affect blood pressure other than other cluster RCTs of dialysate composition; Inability to measure blood pressures in an upper arm; Pregnancy, anticipated pregnancy, or breastfeeding; Unmeasurable SBP (e.g., have left ventricular assist device); Life expectancy < 4 months; Planned transition to home dialysis within 3 months; Planned move to a different dialysis unit within 3 months; Other reasons as determined by treating clinician, reasons will be recorded.