Studying fat around the heart in people with heart failure
Compares fat around the heart with heart function in adults with heart failure.
Plain-language title generated from the registry record
Registry title: The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Leicester, United KingdomSee the site
Where in United Kingdom
- Glenfield Hospital, University Hospitals of LeicesterLeicester, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Leicester
- Trial code
- NCT06768437
- Record updated
- 30 April 2026
- Original description
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.Read full original descriptionShow less
The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.
Inclusion: Participant is willing and able to give informed consent for participation in the study; Aged ≥18 years old; Diagnosed with HFpEF by an experienced cardiologist or signs and symptoms of heart failure with a HFA-PEFF score ≥5; Able to understand written English.
Exclusion: Severe primary valvular heart disease; HFpEF due to infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy/pericardial disease or congenital heart disease; Known heritable, idiopathic or drug-induced pulmonary arterial hypertension; LV ejection fraction <45%; Recovered ejection fraction (previous ejection fraction <40%) unless reduced ejection fraction was in context of tachycardia induced cardiomyopathy (eg atrial fibrillation/atrial flutter); Absolute contraindications to cardiac CT or MRI including estimated glomerular filtration rate (eGFR) ≤30ml/min/1.73m2. Patients with MRI-compatible devices are be excluded; Women who are pregnant.