Blood Microbial DNA Study in Crohn's Disease After Bowel Surgery
Looks at blood microbial DNA in people with Crohn's disease after bowel surgery.
Plain-language title generated from the registry record
Registry title: Unraveling the Blood Microbiome in Postoperative Recurrence of Crohn's Disease
Key facts
- Where
- Rotterdam, NetherlandsSee the site
Where in Netherlands
- Erasmus Medical CenterRotterdam, NetherlandsNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Erasmus Medical Center
- Trial code
- NCT06770140
- Record updated
- 13 January 2025
- Original description
Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however, this role remains unclear to date. We hypothesize to detect tiny fragments of microbial DNA from the gut in the bloodstream, due to disruption in the natural defences of the gut lining. If this is true, it may hold the key to understanding why Crohn's disease recurs after surgery.Read full original descriptionShow less
Unraveling the Blood Microbiome in Postoperative Recurrence of Crohn's Disease
Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however, this role remains unclear to date. We hypothesize to detect tiny fragments of microbial DNA from the gut in the bloodstream, due to disruption in the natural defences of the gut lining. If this is true, it may hold the key to understanding why Crohn's disease recurs after surgery.
Our objective in this study is to test retrospectively, if we can detect any difference in microbial DNA from the blood of ileocolonic resection (ICR) patients that do and do not show recurrence at the time of follow-up endoscopy at 6 months.
Inclusion: Diagnosis of Crohn's Disease; Adult ≥ 16 years; Undergoing an ileocolonic resection or reresection; Written informed consent.
Exclusion: Use of antibiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected; Use of probiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected; Not willing to collect extra biosamples.