Tracking knee pain after a procedure that blocks knee arteries in knee osteoarthritis
Follows adults with knee osteoarthritis who have genicular artery embolization, tracking knee pain over time.
Key facts
- Who runs it
- University of Chicago
- Where
- Chicago, United StatesSee the site
- Trial code
- Registry title
- Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 1 Oct 2023
- Expected to end
- 1 Oct 2028
- Type of study
- Observational
- Treatments tested
- Registry (N/A)
- Record updated
- 13 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with knee pain from knee osteoarthritis that has not improved with usual medicines. They will have genicular artery embolization (GAE), a procedure that blocks small blood vessels in the knee.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Knee osteoarthritis grade 1-3 on the Kellgren-Lawrence scale, seen on standing knee X-rays. Pain in one or both knees for more than 6 months. People cannot have knee replacement surgery, or they prefer GAE.
- Earlier treatment
- Knee pain did not get better with conservative treatment such as Nonsteroidal anti-inflammatory drugs or acetaminophen. No corticosteroid injection in the affected knee within 3 months. No earlier surgery on the affected knee, except arthroscopy.
Main reasons for not taking part
- Active cancer or active infection of the affected knee
- Platelets <50,000/uL or INR >2.0, unless anticoagulation can be reversed or radial/pedal access is used
- Rheumatoid arthritis or other seronegative arthropathy, or grade 4 osteoarthritis of the affected knee
- Pregnancy or expected pregnancy, GFR <30, or severe allergic reaction to iodinated contrast
- Body weight >400 lbs (181 kg)., moderate to severe pain in other leg joints, or peripheral arterial disease (Rutherford Grade 2 or greater) of the treated leg
The registry criteria, word for word
Show all 18 criteriaShow less
Who can take part
- Patients aged >=18
- Bilateral or unilateral knee pain attributed to knee osteoarthritis (KOA). For bilateral KOA patients, the more severe knee will be permitted inclusion to the registry
- Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale
- Knee pain >6 months refractory to conservative medical management (Nonsteroidal anti-inflammatory drugs, acetaminophen, etc.)
- Not eligible for surgical knee replacement or patient's personal preference to undergo Genicular Artery Embolization (GAE) for reasons such as minimally invasiveness of GAE
Who cannot take part
- Corticosteroid injection of the affected knee within 3 months of enrollment
- Previous surgery (excluding arthroscopy) of the affected knee
- Active malignancy
- Active infection of the affected knee
- Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)
- Platelets <50,000/uL, INR >2.0 (unless on anticoagulation that can be reversed or performing radial/pedal access without reversal)
- Glomerular Filtration Rate (GFR) <30
- Rheumatoid arthritis or other seronegative arthropathy
- Grade 4 per Kellgren-Lawrence Grading Scale of the affected knee
- Pregnancy or expected pregnancy
- Anaphylactic reaction to iodinated contrast
- Moderate to severe pain in other lower limb joints
- Body weight >400 lbs. (prohibiting safe angiography)
Where in United States
- University of Chicago Duchossois Center for Advanced MedicineChicago, United StatesContact: Natasha Rodwell, Bachelor of Science in NursingTaking people
About the trial
What the trial wants to find out
The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.
The group in the trial
- Registry
Since this is a registry all enrolled patients are part of one group and will be followed for one year from the respective date of procedure.
Treatment: Registry (N/A)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis (GAE)
- Plain-language title
- Tracking knee pain after a procedure that blocks knee arteries in knee osteoarthritisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 13 May 2026