Studies pain and sex hormones in endometriosis and migraine
Compares pain sensitivity and hormone levels in people with endometriosis, migraine, or both.
Key facts
- Who runs it
- Washington University School of Medicine
- Where
- St Louis, United StatesSee the site
- Trial code
- Registry title
- Endometriosis and Migraine
- Status
- Recruiting
- People taking part
- 120 people, planned
- Started
- 12 Feb 2025
- Expected to end
- 1 Jan 2030
- Type of study
- Observational, 4 groups
- Treatments tested
- Thermal stimuli
- Pressure stimuli
- Pain ratings
- Conditioned pain modulation (CPM) response
- Hormonal assessment
- Record updated
- 13 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for girls and women with migraine, endometriosis, or both, and healthy volunteers with no history of chronic pain.
- Age
- 12 to 45 years
- Sex
- Female (assigned female sex at birth)
- Disease stage
- Diagnosed endometriosis, migraine, or both. Healthy volunteers must have no history of chronic pain.
- Earlier treatment
- Cannot currently use dopamine agonist or SSRI medications.
Main reasons for not taking part
- Pregnancy or breastfeeding
- Prolactinoma
- Psychiatric, neurological, endocrinological or developmental conditions with medications for them
- Current use of dopamine agonist or SSRI medications
- Ages 12-17 without a parent or legal guardian willing to sign consent and answer surveys
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine
- Healthy control subjects with no history of chronic pain
- Age 12-45
- Assigned female sex at birth
Who cannot take part
- Current use of dopamine agonist or SSRI medications
- Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions
- For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health
- Pregnancy or breastfeeding
- Presence of prolactinoma
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 45 years old?
Where in United States
- Washington University School of MedicineSt Louis, United StatesContact: Alana McMichaelTaking people
About the trial
What the trial wants to find out
This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.
The 4 groups in the trial
- migraine
patients with migraine
Treatment: Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, and Hormonal assessment
- Endometriosis
patients with endometriosis
Treatment: Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, and Hormonal assessment
- migraine and endometriosis
patients with migraine and endometriosis
Treatment: Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, and Hormonal assessment
- control
healthy participants with no migraine or endometriosis
Treatment: Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, and Hormonal assessment
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mechanisms Underlying Endometriosis and Migraine Comorbidity
- Plain-language title
- Studies pain and sex hormones in endometriosis and migraineGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06785129, who can take part
- Record updated
- 13 July 2026