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Studies how aspirin is processed in pregnant people at risk of preeclampsia

Observes aspirin processing and metabolic markers in pregnant adults at risk of preeclampsia.

Key facts

Who runs it
University of Tennessee Graduate School of Medicine
Where
Knoxville, United StatesSee the site
Trial code
Registry title
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Status
Recruiting
People taking part
50 people, planned
Started
1 Jan 2025
Expected to end
31 Dec 2028
Type of study
Observational
Record updated
10 September 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for pregnant women under 16 weeks of pregnancy who are advised to take aspirin to help prevent pre-eclampsia.

Age
18 to 45 years
Sex
Women only
Disease stage
Pregnant, under 16 weeks of pregnancy, at risk of pre-eclampsia (1 high risk factor or 2 or more moderate risk factors).
Earlier treatment
Must have been advised aspirin by an obstetrician or maternal-fetal medicine specialist and be willing to take it. Cannot currently take NSAIDs for another reason, other immune-modulating drugs or biologics, steroids, or blood thinners.

Main reasons for not taking part

  • Type 1 or type 2 diabetes, or current gestational diabetes
  • Platelet disorder, bleeding disorder or thrombophilia
  • Medical reason not to take aspirin
  • Molar pregnancy or kidney disease
  • Cannot speak, read or communicate in English, or cannot give informed consent

This trial only enrols pregnant participants. The registry sentence this rests on: Gestational age at enrollment <16 weeks

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

  • Recommended aspirin for pre-eclampsia prevention by OB/GYN or MFM specialist based on ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors); Willingness to adhere to aspirin therapy; Willingness to undergo 2h OGTT for serum and urine collection in addition to survey collection, indirect calorimetry, body composition measures, neonatal measures, etc; Gestational age at enrollment <16 weeks; Ability to speak, read, and communicate via English

Who cannot take part

  • Type 2 Diabetes Mellitus; Type 1 Diabetes Mellitus; Current gestational diabetes mellitus; Current/active platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura/ITP, thrombotic thrombocytopenic purpura/TTP, von Willebrand disease, etc.); Thrombophilia; Current use of NSAID for other indication (indomethacin, ibuprofen, etc.); Current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors, etc.); Current or recent use of steroids; Current use of prophylactic or therapeutic anticoagulation; Medical contraindication to aspirin therapy; Molar pregnancy; Renal disease; Inability or unwillingness to give informed consent; Current psychiatric illness/social situation that would limit compliance with study requirements, as determined by the principal investigators

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 45 years old?

Where in United States

  • University of Tennessee Medical CenterKnoxville, United StatesContact: Rebecca Purvis, MDTaking people

About the trial

What the trial wants to find out

This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.

The group in the trial

  • Pregnant individuals at risk for preecampsia

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Plain-language title
Studies how aspirin is processed in pregnant people at risk of preeclampsiaGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT06802861, who can take part
Record updated
10 September 2025