Studies how depression and antidepressants affect body heat responses in adults
Compares skin blood flow and sweating during heat in adults with depression.
Plain-language title generated from the registry record
Registry title: Impact of Depression on Thermoregulation
Key facts
- Where
- University Park, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT06805851, who can take part
Where in United States
- Noll LaboratoryUniversity Park, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Penn State University
- Trial code
- NCT06805851
- Record updated
- 3 February 2026
- Original description
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.Read full original descriptionShow less
Thermoregulatory Responses to Heat Stress in Adults With Major Depressive Disorder With and Without Antidepressant Treatment
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.
Inclusion: Non-depressed adults aged 18-40 years; OR adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment; OR adults aged 18-40 years with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a selective serotonin reuptake inhibitor; OR aged 18-40 years adults with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor; All participants will be asymptomatic and no signs/symptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription (chest pain or pressure, dizziness, joint pain, and signs of cardiovascular disease); Systolic blood pressure 140 mmHg and diastolic pressure 90 mmHg at screening; Non-diabetic; Not taking any other medications that might affect the physiological variables of interest (beta blockers, tricyclic antidepressants, antipyretics, diuretics, etc.); Between the 20th and 80th percentiles for sex- and age-appropriate VO2max according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription; English proficiency; Capable of providing informed consent.
Exclusion: Plan to have surgery or relocate outside the area within the next year; Medications that could alter cardiovascular or thermoregulatory responses to exercise (beta blockers, antipyretics, tricyclic antidepressants, diuretics, etc.); Illegal/recreational drug use; Use of psychoactive or psychopharmacological drugs other than SSRI and SNRIs within one year of participating; Allergy to latex or adhesive; Any bleeding disorders, gastric ulcers, allergies to NSAIDS, asthma, kidney/liver disorders, and taking any other anticoagulants; History of Crohn's disease, diverticulitis, or similar gastrointestinal disease; Co-morbid psychiatric disorders (psychosis, schizophrenia, bipolar disorder, panic disorder, obsessive compulsive disorder, etc.); BMI > 35; Are pregnant or planning to become pregnant in the next 12 months; Concurrently participate in another study involving physical activity or weight loss; Tobacco use; Exertional chest pain or musculoskeletal pain; Contraindications to a maximal exercise test or an indication for early termination of the exercise test according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription; Abnormal resting or exercise electrocardiogram (ECG); Active suicidal ideation (moderate or high suicidality).