Under construction – not a live service
Sign in
Taking people in United StatesNo phase

Tests magnetic brain stimulation during sleep for depression

Tests magnetic brain stimulation during sleep in adults with major depression.

Plain-language title generated from the registry record
Registry title: Sleep TMS for Depression

Key facts

Where
Stanford, United StatesSee the site

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 65 years old?

Source: NCT06824415, who can take part

Where in United States

  • Stanford UniversityStanford, United StatesTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
Stanford University
Trial code
NCT06824415
Record updated
23 June 2026
Original description
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.Read full original descriptionShow less

Optimizing Depression Treatment Through Sleep-state Brain Stimulation

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Inclusion: Adults ages 18-65 years; Current Major Depressive Disorder (MDD) diagnosis; Failed ≥1 antidepressant medication; Moderate-to-severe depression; Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment; Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.

Exclusion: Significant head injury/neurological disorder; Intellectual disability; Pregnancy or postpartum; TMS/MRI contraindications; Active substance use/suicidal ideation.

ClinicalTrials.gov NCT06824415