Testing melatonin supplement in midlife women with menopause transition and high blood pressure
Tests melatonin supplement in midlife women with perimenopause and high blood pressure.
Plain-language title generated from the registry record
Registry title: Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial
Key facts
- Where
- Rochester, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 55 years old?
Source: NCT06826755, who can take part
Where in United States
- Mayo Clinic in RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06826755
- Record updated
- 13 August 2026
- Original description
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.Read full original descriptionShow less
Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.
Inclusion: Age 40-55 years old; Female individuals with intact uterus and at least one ovary; Hypertension; o Defined as a prior diagnosis of hypertension, use of antihypertensive agents, or office SBP/DBP ≥130/80 mmHg; On stable medical regimen (≥ 2 months) if taking other medications.
Exclusion: Prescription sleeping medications or melatonin supplementation; History of substance use disorder; History of suicidal ideation; Active cancer; History of clinically diagnosed anemia (within the past 5 years) or low hemoglobin levels (<11.6 g/dL) within the past 12 months; Pregnant or lactating; Use of tobacco, nicotine or vaping products; Night shift work; On prescription aspirin; Severe lactose intolerance; Severe daytime sleepiness (score >15 at the Epworth Sleepiness Scale [ESS])81; Current or recent (within the past 2 months) participation in other research studies at the discretion of study investigators; Inability to provide written consent and/or to speak and read English; Any other medical, geographic, or social factor making study participation impractical.