Testing two exercise programs in people with familial high cholesterol
Tests high-intensity and moderate exercise programs in adults with inherited high cholesterol.
Plain-language title generated from the registry record
Registry title: High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)
Key facts
- Where
- Granada, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06833944, who can take part
Where in Spain
- Virgen de las Nieves University HospitalGranada, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
- Trial code
- NCT06833944
- Record updated
- 22 September 2026
- Original description
This study has one main objective:Read full original descriptionShow less
Unraveling the Potential of Physical Activity in the Treatment of Familial Hypercholesterolemia: Impact of Exercise on Cardiorespiratory Fitness, Atherosclerosis Progression, and Underlying Mechanisms
This study has one main objective:
a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects.
The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique
Inclusion: Individuals with a diagnosis of genetic FH; > 18 years old; Minimum follow-up of 1 year in the Vascular Risk Clinic of the Virgen de las Nieves University Hospital (HUVN); Clinical and treatment stability; Non-pathological angio-TAC of coronary arteries in the 2 years prior to the study (for participants >45 years old).
Exclusion: History of clinical CVD (ischemic heart disease, stroke, and/or peripheral arterial disease); Inability to read, understand and sign the informed consent; Contraindications to exercise.