MOTION Clinical Trial
Key facts
- Who runs it
- Moximed
- Where
- Chicago, Columbus, Davis, New York, Oak Brook, Oceanside, Omaha, Sacramento, and San Antonio, United StatesSee the 9 sites
- Trial code
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 13 Feb 2025
- Expected to end
- 30 Jun 2030
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- MISHA Knee System
- Non-Surgical Treatment
- Record updated
- 14 July 2026
Who can take part
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Activity exacerbated knee pain isolated to the medial compartment and not global in nature
- WOMAC pain ≥ 40
- Failed to find relief in non-surgical treatment modalities
Who cannot take part
- Propensity for restrictive scar formation or adhesions with prior procedures
- Active or recent knee infection
- Inflammatory joint disease, including sequelae of viral infections
- Suspected or documented allergy or hypersensitivity to cobalt, chromium, nickel or other metals
- History of keloid, hypertrophic or contracture scaring
- Large medial osteophyte(s) or considerable extruded meniscus that may interfere with the placement or function of the device
- Poor bone quality (e.g., bony erosion, osteopenia, osteoporosis)
- Ligamentous instability
Where in United States
- Rush University Medical CenterChicago, United StatesContact: Adam Yanke, MDTaking people
- Ohio State Jameson Crane Sports Medicine InstituteColumbus, United StatesContact: Robert Magnussen, MDTaking people
- UC Davis Department of Orthopaedic SurgeryDavis, United StatesContact: Rose S WeinsteinNo longer taking part
- NYU Langone HealthNew York, United StatesContact: Rose S WeinsteinNo longer taking part
- Genesis Orthopedics & Sports MedicineOak Brook, United StatesContact: Hythem Shadid, MDTaking people
- Scripps Clinic JeffersonOceanside, United StatesContact: Tianyi Wang, MDTaking people
- University of Nebraska Medical CenterOmaha, United StatesContact: Matthew Tao, MDTaking people
- Sutter HealthSacramento, United StatesContact: Rose S WeinsteinNo longer taking part
- UT Health San AntonioSan Antonio, United StatesContact: Thomas DeBerardino, MDTaking people
About the trial
What the trial wants to find out
Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment.
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This is the first randomized head-to-head study comparing outcomes from subjects treated with the MISHA Knee System.
The 2 groups in the trial
- MISHA Knee SystemTreatment being tested
The MISHA Knee System is an extra-capsular knee implant intended to reduce loads on the medial knee. The implant consists of an absorber located between bases fixed with locking screws to the medial cortices of the distal femur and proximal tibia. The implant shares the load with the medial knee joint and articulating ball-and-sockets allow the device to accommodate the natural motions of the knee.
- Non-Surgical TreatmentExisting treatment, for comparison
The non-surgical arm includes assist devices, physical conditioning, prescription or nonprescription medications, creams, vitamins, or supplements, intra-articular Injections, physical therapy and weight loss.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of the MISHA® Knee System for Symptom Relief in Subjects With Medial Knee Osteoarthritis Versus the Use of Non-surgical Treatment: Randomized Clinical Trial and Comparison of Therapies for Medial Knee Osteoarthritis
- Record updated
- 14 July 2026