Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
Key facts
- Where
- Omaha, United StatesSee the site
- Phase
- Phase 1/2
Where in United States
- Children's Nebraska, 8200 Dodge StOmaha, United StatesContact: Jeffrey D Salomon, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Nebraska
- Trial code
- NCT06882772
- Record updated
- 30 October 2026
- Original description
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe. However, it's suitability for infants and young children with congenital heart disease (CHD) has yet to be determined.Read full original descriptionShow less
Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids, A Phase IIa Clinical Trial
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe. However, it's suitability for infants and young children with congenital heart disease (CHD) has yet to be determined.
This study will examine butyric acid supplementation in infants and children, ages 1 month to 3 years, with CHD who require cardiac surgery with cardiopulmonary bypass. Study goals include determining the safety and tolerability of butyric acid supplementation before cardiac surgery, and to identify changes in gut microbial communities, metabolic profile, and genetic markers intestinal function. Also, the study seeks to establish a reduction in inflammation (inflammatory signaling) after cardiopulmonary bypass (CPB) in participants receiving butyric acid.
Inclusion: Infants and Children undergoing cardiac surgery with cardiopulmonary bypass.
Exclusion: Antibiotics, surgery, or chemotherapy within the past 8 weeks; Continuous enteral feeds before surgery; GI pathology or intestinal surgery (excluding G-tube); Liver disease with elevated transaminitis or dialysis-dependent renal disease.