Amyloid scans with 124I-evuzamitide in back and wrist nerve conditions
Tests amyloid scans in spinal stenosis or carpal tunnel syndrome.
Plain-language title generated from the registry record
Registry title: 124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel Syndrome
Key facts
- Where
- Knoxville, United StatesSee the site
- Phase
- Phase 2
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 60 or older who had spine or carpal tunnel surgery and whose removed tissue tested positive for amyloid (a protein build-up).
- Age
- 60 years or older
- Sex
- All sexes
- Disease stage
- Tissue from laminectomy or carpal tunnel release surgery must be Congo red positive, with either extensive or mild/moderate amyloid. Mild/moderate amyloid also needs at least one other bone or joint problem, such as carpal tunnel syndrome, lumbar spinal stenosis, trigger finger, biceps tendon rupture or joint replacement.
- Earlier treatment
- Laminectomy or carpal tunnel release surgery with a tissue sample tested. People taking heparin or heparin derivatives for anticoagulation cannot join.
- Biomarker or test result
- Congo red positive ligamentum flavum or tenosynovial tissue sample.
Main reasons for not taking part
- On dialysis
- Confirmed systemic amyloidosis outside muscle and bone tissue
- Taking heparin or heparin derivatives for anticoagulation
- Cannot lie still for about 40 minutes on the PET/CT scanner
- History of iodine (potassium iodide) allergy
Read by machine on 12 November 2026.
Where in United States
- University of Tennessee Graduate School of MedicineKnoxville, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Tennessee Graduate School of Medicine
- Trial code
- NCT06907849
- Record updated
- 21 July 2026
- Original description
This clinical trial will use the amyloid-binding radiotracer, 124I-evuzamitide, to potentially detect amyloid, in the heart and elsewhere, in patients who have a history of lumbar spinal stenosis and/or carpal tunnel syndrome.Read full original descriptionShow less
PET/CT Imaging Of Subjects With Lumbar Spinal Stenosis Or Carpal Tunnel Syndrome Using Amyloid-Reactive Peptide 124I-Evuzamitide
This clinical trial will use the amyloid-binding radiotracer, 124I-evuzamitide, to potentially detect amyloid, in the heart and elsewhere, in patients who have a history of lumbar spinal stenosis and/or carpal tunnel syndrome.
Inclusion: Must be ≥ 60 years of age; Must have given written informed consent (signed and dated) and any authorizations required by local law and be able to comply with all study requirements; Must have a Congo red positive ligamentum flavum or tenosynovial specimen analysis after laminectomy or carpal tunnel release surgery that is visually categorized as either "extensive" amyloid load or "mild/moderate" amyloid load by an experienced reviewer; Those with mild/moderate amyloid load in the connective tissue who also have a history of at least one other orthopedic clinical manifestation, including, but not limited to, carpal tunnel syndrome, lumbar spinal stenosis, trigger finger, biceps tendon rupture, and shoulder/hip/knee arthroplasty; Females must be non-pregnant and non-lactating.
Exclusion: History of iodine (potassium iodide) allergy; Subjects on dialysis; Subjects with a confirmed diagnosis of systemic amyloidosis, other than musculoskeletal tissue; Inability or unwillingness to comply with the study requirements; Subjects taking heparin, or heparin derivatives (e.g. low molecular weight heparins) for anticoagulation; Inability to lie still for ~40 minutes on the PET/CT scanner; Other reason that would make the subject inappropriate for entry into this study.