Amyloidosis trials in United States

In United States 69 Also abroad 184

69 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Where
Ann Arbor, Atlanta, Baltimore, Boston, Charleston, Chicago, Cleveland, Columbus, Dallas, Denver, Detroit, Durham, Falls Church, Houston, Indianapolis, Jacksonville, Kansas City, Lexington, Los Angeles, Madison, New Haven, New York, Palo Alto, Philadelphia, Pittsburgh, Plano, Portland, Richmond, Rochester, San Diego, Tucson, Washington D.C., Weston
Age
18 years to 90 years
People
1,200 worldwide
Run by
Intellia Therapeutics
See details and how to joinNCT06128629 · EU 2023-507220-23-00
No phaseTaking people
Multicenter Study for the Validation of an AI-based ECG Platform for Early Cardiac Amyloidosis Diagnosis
Where
Evanston
Age
18 years and over
People
2,200 worldwide
Run by
Idoven 1903 S.L.
See details and how to joinNCT06978660
Phase 1Taking people
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
Where
Charlotte, Denver, Duarte, Houston, Irvine, New York, Philadelphia, San Francisco
Age
18 years and over
People
180 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05652335 · EU 2023-503679-12-00
No phaseNot yet taking people in United States
Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry
Where
Richmond
Age
18 years and over
People
1,000
Run by
Virginia Commonwealth University
See details and how to joinNCT05974644
Phase 2Taking people
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis
Where
Aurora, Boston, Hackensack, Los Angeles, Nashville, New Haven, Rochester, Salt Lake City
Age
18 years to 64 years
People
60 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07224672 · EU 2025-522803-60-00
No phaseNot yet taking people in United States
PET/CT Imaging in Carriers of TTR Mutations
Where
Dallas
Age
30 years to 80 years
People
80
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07591038
No phaseTaking people
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
Where
Chapel Hill
Age
18 years to 120 years
People
15,000
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT01137643
No phaseTaking people
CCM OPEN HF Registry
Where
Ann Arbor, Boston, Browns Mills, El Paso, Germantown, Hackensack, Haddon Heights, Kansas City, Londonderry, Lynchburg, Mesa, Milwaukee, Minneapolis, Newark, Novi, Oklahoma City, Orlando, Phoenix, Portland, Surprise, Tampa, Tyler, Vancouver, West Reading, Ypsilanti
Age
18 years and over
People
5,500
Run by
Impulse Dynamics
See details and how to joinNCT07112924
Early phase 1Not yet taking people in United States
A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement
Where
Palo Alto
Age
18 years and over
People
5
Run by
Stanford University
See details and how to joinNCT07615270
No phaseTaking people
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Where
Birmingham, Boston, Charlotte, Columbus, Dallas, Durham, Los Angeles, New York, Richmond, Salt Lake City, San Francisco, Weston
Age
40 years and over
People
400
Run by
Tufts Medical Center
See details and how to joinNCT06365060
No phaseNot yet taking people in United States
PET Imaging Study Using Evuzamitide to Detect Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans and Elevated TAD1 Levels
Where
Boston, Dallas, New York
People
25
Run by
Lorena Saelices
See details and how to joinNCT07538518
Phase 3Enrolling by invitation
A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Where
Baltimore, Beverly Hills, Boston, Chicago, Cleveland, Columbus, Dallas, Durham, Glenview, Indianapolis, Kansas City, La Jolla, Nashville, New York, Omaha, Philadelphia, Phoenix, Rochester, Salt Lake City, Stanford, St Louis, Washington D.C.
Age
18 years and over
People
700 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT06679946
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Abington, Allentown, Ann Arbor, Austin, Baltimore, Boston, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Detroit, Durham, Falls Church, Farmington Hills, Gainesville, Glenview, Greenville, Hershey, Honolulu, Houston, Indianapolis, Kansas City, La Jolla, Lancaster, Los Angeles, Manhasset, Murray, Nashville, New Haven, New Orleans, New York, Norfolk, Omaha, Orange, Pasadena, Philadelphia, Phoenix, Plano, Portland, Richmond, Rochester, Rosedale, San Francisco, Santa Rosa, Spokane, Stanford, St Louis, The Bronx, Tupelo, Washington D.C.
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
Phase 3Taking people
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Where
Atlanta, Aurora, Austin, Baltimore, Boston, Brandon, Charleston, Charlotte, Charlottesville, Chicago, Cleveland, Columbus, Dallas, Detroit, Evanston, Falls Church, Gainesville, Houston, Indianapolis, Kansas City, Laguna Hills, La Jolla, Lancaster, Manhasset, Miami, New York, Norfolk, Norwich, Philadelphia, Plano, Portland, Richmond, Rochester, Salt Lake City, Seattle, Spokane, Stanford, St Louis, The Bronx, Tucker, Washington D.C.
Age
18 years to 85 years
People
1,750 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07052903 · EU 2024-519917-72-00
No phaseTaking people
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
Where
Austin, Baltimore, Boston, Columbus, Durham, Houston, Iowa City, Jacksonville, Kansas City, La Jolla, Los Angeles, New York, Philadelphia
People
1,500 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT04561518
No phaseTaking people
Elevated Rate Pacing of Cardiac Amyloidosis
Where
Minneapolis
Age
18 years and over
People
10
Run by
University of Minnesota
See details and how to joinNCT07583823
No phaseTaking people
DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting
Where
Beverly Hills, Boston, Charlotte, Dallas, Honolulu, Kansas City, La Jolla, Memphis, Naples, New Brunswick, Philadelphia, St Louis, Tucson
Age
18 years and over
People
2,000 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07358078
No phaseTaking people
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
Where
Iowa City
People
10 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT05040373
Phase 3Taking people
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
Where
Aurora, Baltimore, Boston, Chapel Hill, Chicago, Dallas, Houston, Nashville, New York, Rochester
Age
18 years to 85 years
People
125 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07223203 · EU 2025-522544-40-00
Phase 2Taking people
Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial
Where
Rochester, Scottsdale
Age
18 years and over
People
96
Run by
Mayo Clinic
See details and how to joinNCT05898646
Phase 2Taking people
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Where
Jacksonville
Age
18 years and over
People
27
Run by
Mayo Clinic
See details and how to joinNCT07285044
No phaseTaking people
SMS-Based Remote Symptom Monitoring for Patients With Plasma Cell Disorders
Where
Rochester
Age
18 years and over
People
150
Run by
Mayo Clinic
See details and how to joinNCT07850284
Phase 1Taking people
A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma
Where
Atlanta, Denver
Age
18 years and over
People
276 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06768489 · EU 2024-515316-44-00
No phaseTaking people
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
Where
Baltimore, Boston, Chicago, Dallas, Danville, Durham, Germantown, Greenville, Houston, Indianapolis, Kansas City, La Jolla, Los Angeles, Manhasset, Milwaukee, Nashville, New Brunswick, New Haven, New York, Philadelphia, Portland, Richmond, Rochester, San Francisco, Seattle, St Louis, Washington D.C.
Age
18 years to 130 years
People
1,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06465810
No phaseTaking people
Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations
Where
Los Angeles
Age
18 years and over
People
320 worldwide
Run by
AstraZeneca
See details and how to joinNCT07654855