Tests tozorakimab for uncontrolled asthma in adults using inhaled steroids
Tests tozorakimab injections against placebo in adults with uncontrolled asthma.
Plain-language title generated from the registry record
Registry title: Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
Key facts
- Where
- Asheville, Austin, Bakersfield, Bellevue, Bellingham, Boerne, Boise, Cutler Bay, Dallas, DuBois, Edmond, El Paso, Farmington Hills, Forney, Grand Island, Grants Pass, Greenville, Hialeah, Horseheads, Huntersville, Huntington Beach, Hutchinson, Kansas City, Kings Mountain, Kingwood, Knoxville, La Mesa, Leesburg, Loma Linda, Long Beach, Louisville, Maspeth, McKinney, Medford, Miami, Miami Lakes, Millville, Milwaukee, Mullica Hill, Newport Beach, Noblesville, Omaha, Orlando, Palmetto Bay, Philadelphia, Pinehurst, Portland, Rock Hill, Roy, San Jose, Smithfield, St Louis, Sugar Land, Tampa, Toledo, Toms River, Victoria, Warren, West Des Moines, White Marsh, Wilmington, Winter Park, and Worcester, United StatesSee the 63 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06932263, who can take part
Where in United States
- AshevilleAsheville, United StatesNo longer taking part
- AustinAustin, United StatesTaking people
- BakersfieldBakersfield, United StatesTaking people
- BellevueBellevue, United StatesNo longer taking part
- BellinghamBellingham, United StatesNo longer taking part
- BoerneBoerne, United StatesTaking people
- BoiseBoise, United StatesNo longer taking part
- Cutler BayCutler Bay, United StatesNo longer taking part
- DallasDallas, United StatesTaking people
- DuBoisDuBois, United StatesNo longer taking part
- EdmondEdmond, United StatesNo longer taking part
- El PasoEl Paso, United StatesTaking people
- Farmington HillsFarmington Hills, United StatesTaking people
- ForneyForney, United StatesNo longer taking part
- Grand IslandGrand Island, United StatesTaking people
- Grants PassGrants Pass, United StatesNo longer taking part
- GreenvilleGreenville, United StatesTaking people
- HialeahHialeah, United StatesNo longer taking part
- HorseheadsHorseheads, United StatesTaking people
- HuntersvilleHuntersville, United StatesNo longer taking part
- Huntington BeachHuntington Beach, United StatesNo longer taking part
- HutchinsonHutchinson, United StatesTaking people
- Kansas CityKansas City, United StatesNo longer taking part
- Kings MountainKings Mountain, United StatesTaking people
- KingwoodKingwood, United StatesTaking people
- KnoxvilleKnoxville, United StatesNo longer taking part
- La MesaLa Mesa, United StatesNo longer taking part
- LeesburgLeesburg, United StatesNo longer taking part
- Loma LindaLoma Linda, United StatesNo longer taking part
- Long BeachLong Beach, United StatesTaking people
- LouisvilleLouisville, United StatesTaking people
- MaspethMaspeth, United StatesTaking people
- McKinneyMcKinney, United StatesNo longer taking part
- MedfordMedford, United StatesTaking people
- MiamiMiami, United StatesNo longer taking part
- Miami LakesMiami Lakes, United StatesNo longer taking part
- MillvilleMillville, United StatesNot yet recruiting
- MilwaukeeMilwaukee, United StatesTaking people
- Mullica HillMullica Hill, United StatesTaking people
- Newport BeachNewport Beach, United StatesTaking people
- NoblesvilleNoblesville, United StatesTaking people
- OmahaOmaha, United StatesTaking people
- OrlandoOrlando, United StatesNo longer taking part
- Palmetto BayPalmetto Bay, United StatesNo longer taking part
- PhiladelphiaPhiladelphia, United StatesTaking people
- PinehurstPinehurst, United StatesNo longer taking part
- PortlandPortland, United StatesTaking people
- Rock HillRock Hill, United StatesTaking people
- RoyRoy, United StatesNo longer taking part
- San JoseSan Jose, United StatesTaking people
- SmithfieldSmithfield, United StatesTaking people
- St LouisSt Louis, United StatesNo longer taking part
- Sugar LandSugar Land, United StatesTaking people
- TampaTampa, United StatesNo longer taking part
- ToledoToledo, United StatesTaking people
- Toms RiverToms River, United StatesTaking people
- VictoriaVictoria, United StatesTaking people
- WarrenWarren, United StatesNo longer taking part
- West Des MoinesWest Des Moines, United StatesNo longer taking part
- White MarshWhite Marsh, United StatesNo longer taking part
- WilmingtonWilmington, United StatesNo longer taking part
- Winter ParkWinter Park, United StatesNo longer taking part
- WorcesterWorcester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- AstraZeneca
- Trial code
- NCT06932263EU 2024-519116-14-00
- Record updated
- 30 October 2026
- Original description
This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.Read full original descriptionShow less
A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants With Uncontrolled Asthma on Medium-to High Dose Inhaled Corticosteroids
This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.
Inclusion: Provision of signed and dated written informed consent prior to any study-specific procedures; Adults aged 18-75, inclusive when signing the informed consent; Documented physician-diagnosis of asthma for at least 12 months; Treated with medium or high dose ICS in combination with LABA; Demonstration of uncontrolled asthma through ACQ-6 score ≥ 1.5 ; Pre-bronchodilator FEV1 ≥ 40% to ≤ 90% of predicted normal; Documented exacerbation history in the last 12 months and biomarker requirements of:; ≥ 2 severe exacerbations OR; 1 severe exacerbation and:; (i) Eosinophils ≥ 150 cells/µl or (ii) FeNo ≥ 25 ppb; Participants need to demonstrate a ≥70% compliance for Asthma Daily Diary; Women of Child Bearing Potential (WOCBP) must have a negative pregnancy test; Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Exclusion: Completed treatment for respiratory infection with antibiotics in the 4 weeks prior to Visit 1; Clinically significant pulmonary disease other than asthma ; Clinically significant aortic stenosis or pulmonary arterial hypertension; Active tuberculosis, hepatitis, HIV, or current diagnosis of cancer or immune complex disease; Unstable cardiovascular disorders; Current smokers, former smokers with >10 pack-years history.