Comparing two lab methods to find cancer spread in lymph nodes in endometrial cancer
Tests two lab methods for checking sentinel lymph nodes removed during surgery for endometrial cancer.
Plain-language title generated from the registry record
Registry title: OSNA Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer
Key facts
- Where
- Rome, ItalySee the site
Where in Italy
- Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Trial code
- NCT06935305
- Record updated
- 18 November 2025
- Original description
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the other arm it will be conducted using the OSNA method.Read full original descriptionShow less
One Step Nucleic Acid Amplification (OSNA) Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer: a Randomized, Multicenter, Controlled Trial (SENT-OSNA Study)
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the other arm it will be conducted using the OSNA method.
Inclusion: Histologically confirmed endometrial cancer; Apparent (pre-operative) FIGO stage I-II; Radical surgery; Attempt of SLN mapping.
Exclusion: Fertility sparing surgery; Neoadjuvant therapy; Previous surgery to pelvic lymph nodes; Uterine sarcoma (including endometrial stromal sarcoma); Dedifferentiated histology; Undifferentiated histology; Lymph nodes with short axis >15 mm at pre-operative imaging.