Breathing Muscle Training for Young People With Type 2 Diabetes

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for young people and young adults with type 2 diabetes. It tests a short daily breathing-muscle training against sham (fake) training.

Age

14 to 40 years

Sex

All sexes can join.

Disease stage

Type 2 diabetes for at least one year, with HbA1C less than 12% (108 mmol/mol).

Main reasons for not taking part

• Type 2 diabetes for more than 18 years
• eGFR less than 60 ml/min/1.73m2
• Albumin-to-creatinine ratio (ACR) greater than 2200mg/g
• Blood pressure greater than 160/100 mm Hg

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 14 and 40 years old?YesNo

What the trial wants to find out

High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only ~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.

The 2 groups in the trial

• IMSTTreatment being tested

  Using the POWERBreathe pressure threshold training device, participants will perform 30 inspiratory maneuvers (5 sets of 6, 1 min rest) 6 days/week for 3 months. This is an over the counter product that will be used according to its instructions. The IMST group will train at 75% maximal inspiratory pressure.

  Treatment: Inspiratory Muscle Strength Training (IMST)

• Sham/PlaceboSham treatment, for comparison

  Using the POWERBreathe pressure threshold training device, participants will perform 30 inspiratory maneuvers (5 sets of 6, 1 min rest) 6 days/week for 3 months. This is an over the counter product that will be used according to its instructions. The Sham group will train at 15% maximal inspiratory pressure.

  Treatment: Sham Training