Tests rapid magnetic brain stimulation for symptoms in Long COVID
Tests rapid magnetic brain stimulation in adults with Long COVID.
Plain-language title generated from the registry record
Registry title: Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
Key facts
- Where
- Albuquerque, United StatesSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06940609, who can take part
Where in United States
- University of New Mexico Health Science CenterAlbuquerque, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of New Mexico
- Trial code
- NCT06940609
- Record updated
- 15 July 2026
- Original description
The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog, depression, and anxiety in patients with Long COVID. The main questions it aims to answer are:Read full original descriptionShow less
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)
The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog, depression, and anxiety in patients with Long COVID. The main questions it aims to answer are:
* Is iTBS effective and feasible for reducing Long COVID symptoms? We will measure these symptoms using the Symptom Burden Questionnaire. * Are there changes in inflammatory brain chemicals associated with treatment with iTBS? We will be looking at levels of choline in the brain, which is thought to be related to inflammation.
Researchers will compare sham versus active forms of iTBS to see if the active group has greater improvement in symptoms.
Participants will complete symptom surveys, cognitive tests, and magnetic resonance imaging scans at the beginning, middle, and end of treatment.
Inclusion: aged 18-80; a documented diagnosis of PASC with evidence of ongoing symptoms as demonstrated by score of 12 on the NIH RECOVER Symptom List; have "brain fog" or cognitive difficulties as one of the ongoing symptoms; are fluent in English; if taking psychotropic medications, have been on stable doses for the past month.
Exclusion: a prior history of other neurological disease, or any history of seizures, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms; history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation; history of ongoing substance/alcohol dependence, to reduce confounding effects on diagnosis and brain imaging; any condition that would prevent the subject from completing the protocol; presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS; recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study; appointment of a legal representative, to avoid coercion of a vulnerable population; any ongoing litigation related to medical diagnosis, or disability, to prevent interference with legal proceedings; any contraindication to MRI; membership in an identified vulnerable population, including minors, pregnant women, and prisoners, so as to prevent coercion.