Online Program Tested for Adults Receiving Stem Cell Transplants for Blood Cancer
Tests an online website for adults with blood cancer before and after stem cell transplant.
Plain-language title generated from the registry record
Registry title: Mosaic Trial for Stem Cell Transplant Recipients
Key facts
- Where
- Chicago, Nutley, and Washington D.C., United StatesSee the 3 sites
Where in United States
- Northwestern University Feinberg School of MedicineChicago, United StatesTaking people
- Hackensack Meridian HealthNutley, United StatesTaking people
- Georgetown University School of MedicineWashington D.C., United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Northwestern University
- Trial code
- NCT06960993
- Record updated
- 30 October 2026
- Original description
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared to using an educational website (control group). Patients will be recruited prior to their scheduled transplant, then randomized to use one of these two study websites throughout the study. They will complete five assessments during the study: one before transplant (baseline) and four after transplant (2, 4, 6, and 8 month follow-ups).Read full original descriptionShow less
Mosaic: RCT of a Digital Health Intervention for English- and Spanish-speaking Stem Cell Transplant Recipients
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared to using an educational website (control group). Patients will be recruited prior to their scheduled transplant, then randomized to use one of these two study websites throughout the study. They will complete five assessments during the study: one before transplant (baseline) and four after transplant (2, 4, 6, and 8 month follow-ups).
The main questions this trial aims to answer are:
1. Compared to patients using the control group website, do patients using the intervention website report greater improvements in general psychological distress, cancer treatment-related distress, physical symptoms, and health-related quality of life? 2. Are these benefits at least partially explained by improvements in perceived preparedness, self-efficacy, and approach coping and/or reductions in avoidant coping and perceived stress? 3. Do some patients benefit more from using the intervention website than others? Specifically, we will examine whether patients' primary language (English/Spanish) and their initial psychological distress are related to the benefit they get from using the intervention website. We will also explore effects of sex, race, ethnicity, and transplant type.
Inclusion: Diagnosed with a hematologic cancer according to medical records; Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites; Aged 18 or older (no upper limit); English or Spanish Proficient; Interested in using a website to learn about stem cell transplant; Ability to understand and willingness to sign an informed consent document and comply with all study procedures.
Exclusion: Undergoing the first in a planned tandem stem cell transplant; Unable to provide meaningful consent (severe cognitive impairment or language difficulties); Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms.