Brain Wave Patterns and Speech in People With Psychosis
Studies brain activity and speech in adults with schizophrenia and healthy volunteers.
Plain-language title generated from the registry record
Registry title: Magnetoencephalography in Psychosis Program
Key facts
- Where
- Montreal, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06978881, who can take part
Where in Canada
- Douglas Mental Health University InstituteMontreal, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Douglas Mental Health University Institute
- Trial code
- NCT06978881
- Record updated
- 18 May 2025
- Original description
This research involves the examination of speech, thinking patterns and symptoms and recordings from brain's activity in patients with schizophrenia. The reserchers are investigating if the electrical waves (recorded indirectly using the resulting magnetic field around our head) are disrupted in psychosis, especially in the language related problems seen in this disorder. To examine language, participants will be asked to complete a speech tasks using the DISCOURSE speech elicitation script in which they will be requested to share their thoughts. For this purpose, the participants will be shown some pictures and asked to describe what they see, discuss a significant event from their life and tell a story in their own words. The description of the pictures and other responses to the tasks will be audio-recorded for later transcription into a written format.Read full original descriptionShow less
Temporal Regularity of Neural Activity and Its Relationship to Psychotic Symptoms
This research involves the examination of speech, thinking patterns and symptoms and recordings from brain's activity in patients with schizophrenia. The reserchers are investigating if the electrical waves (recorded indirectly using the resulting magnetic field around our head) are disrupted in psychosis, especially in the language related problems seen in this disorder. To examine language, participants will be asked to complete a speech tasks using the DISCOURSE speech elicitation script in which they will be requested to share their thoughts. For this purpose, the participants will be shown some pictures and asked to describe what they see, discuss a significant event from their life and tell a story in their own words. The description of the pictures and other responses to the tasks will be audio-recorded for later transcription into a written format.
The researches will examine the brain regions using Magnetoencephalography (MEG) and Magnetic Resonance Imaging (MRI). MEG and MRI are both non-invasive functional brain imaging technologies. MRI collects structural information and creates images of the brain while MEG collects magnetic activity from neurons, visualized as brain waves. The MRI machine uses a large magnet to help create images while MEG captures the fluctuations in the small magnetic fields resulting from brain's activity. Participants will also undergo a clinical and neurocognitive assessments.
This project design involves 50 individuals who will take part in the study; 25 affected and 25 healthy volunteers aged 18 to 50 years.
Inclusion: Clinical diagnosis of schizophrenia as per DSM-5 criteria; Aged between 18 and 50 years; In a stable phase of the illness (no change in Global Functioning > 10 units within 1 month before the MEG scan assessed using the Global Assessment of Functioning Scale); Healthy volunteers aged between 18 and 50 years; Matched to patients for age (within 2 years), sex, and parental occupational status (rated by NS-SEC).
Exclusion: History of head trauma, major neurological disorders (e.g., epilepsy), somatic disorders with neurological complaints (e.g., multiple sclerosis), or intellectual disabilities; Diagnosis of substance use disorder (current or within the last year) as per DSM-5; History of head trauma, major neurological disorders (e.g., epilepsy), somatic disorders with neurological complaints (e.g., multiple sclerosis), or intellectual disabilities; Diagnosis of substance use disorder (current or within the last year) as per DSM-5; Personal or family history of psychotic disorder; Inability to speak English or French; Unsuitable for MRI due to safety concerns (e.g., metal in the body, pregnancy, tinnitus); Healthy Controls; Inability to speak English or French; Unsuitable for MRI due to safety concerns (e.g., metal in the body, pregnancy, tinnitus).
Patients:.