Brain stimulation with treadmill training for walking in multiple sclerosis
Tests brain stimulation with treadmill walking practice in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
Key facts
- Where
- Toledo, SpainSee the 2 sites
Where in Spain
- Asociación de Esclerosis Múltiple de ToledoToledo, SpainTaking people
- Universidad de Castilla La ManchaToledo, SpainEnrolling by invitation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Castilla-La Mancha
- Trial code
- NCT06986278
- Record updated
- 29 May 2025
- Original description
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.Read full original descriptionShow less
Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
Inclusion: Ability to understand and follow instructions; Diagnosis of Multiple Sclerosis according to McDonald criteria; Expanded Disability Status Scale (EDSS) between 1 and 6; Stable condition in the last three months.
Exclusion: Uncontrolled epilepsy; Diagnosis of psychiatric disorder; Peripheral neurological injury of lower limbs; Metal objects in the head; Fractures or fissures in the skull; Presence of any implanted electronic device (pacemaker, baclofen pump); Presence of ulcers in the harness attachment area; Osteoporotic fractures in the last 2 years; Height > 190 cm; Weight > 120 kg.