Multiple sclerosis trials in Spain

In Spain 35 Also abroad 503

35 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)
Where
Madrid, Seville
Age
10 years to 17 years
People
12 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07161258 · EU 2024-519800-28-00
Phase 3Taking people
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Where
A Coruña, Badalona, Barakaldo, Barcelona, Castilleja De La Cuesta, Madrid, Majadahonda, Malaga, Murcia, Salt, Sevilla, Valencia, Vigo
Age
18 years to 60 years
People
990 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07299019 · EU 2025-524322-18-00
Phase 3Taking people
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Where
A Coruña, Badalona, Barakaldo, Castilleja De La Cuesta, Madrid, Majadahonda, Murcia, Salt, Vigo
Age
18 years to 60 years
People
705 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07067463 · EU 2025-524316-11-00
Phase 3Taking people
Efficacy and safety study of frexalimab (SAR441344) in adults with relapsing forms of multiple sclerosis
Where
Barcelona, Córdoba, Las Palmas De Gran Canaria, Madrid, Málaga, Murcia, Pozuelo de Alarcón, Sevilla, Valladolid
Age
18 years to 64 years
People
386 worldwide
Run by
Sanofi-Aventis Recherche & Developpement
See details and how to join2023-504358-36-00 · EU 2023-504358-36-00
Phase 3Taking people
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Where
Barcelona, Córdoba, Madrid, Majadahonda, Málaga, Murcia, Salt, Sevilla, Valencia
Age
40 years to 70 years
People
400 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06846281 · EU 2023-509275-17-00
No phaseTaking people
Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple Sclerosis
Where
Barcelona
Age
18 years to 65 years
People
30
Run by
Clarity Health Technologies, Inc
See details and how to joinNCT07310862
Phase 3Taking people
A Randomized, Double-blind, Study to Demonstrate Pharmacokinetic Similarity, and Evaluate Safety, Immunogenicity, Pharmacodynamics and Clinical Effects between ABP 692 and Ocrevus® (Ocrelizumab) in Subjects with Relapsing-remitting Multiple Sclerosis
Where
Alcorcón, Barcelona, Castilleja De La Cuesta, Denia, Madrid, Malaga, Málaga, Salt, Sevilla, Valencia, Vigo
Age
18 years to 64 years
People
125 worldwide
Run by
Amgen Inc.
See details and how to join2024-512914-16-00 · EU 2024-512914-16-00
Phase 1Taking people
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Where
Barcelona, Valencia
Age
18 years to 60 years
People
24 worldwide
Run by
Autolus Limited
See details and how to joinNCT07139743 · EU 2024-519552-93-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Where
Albacete, Alicante, Barakaldo, Barcelona, Castilleja de la Cuesta, El Palmar, Jerez de la Frontera, Las Palmas GC, L'Hospitalet de Llobregat, Lleida, Logroño, Madrid, Málaga, Pozuelo de Alarcón, Salamanca, Seville, Torrejón de Ardoz, Valencia
Age
18 years to 65 years
People
1,275 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07225504
Phase 3Taking people
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Where
Barakaldo, Barcelona, Córdoba, Donostia, Girona, Las Palmas De Gran Canaria, L'hospitalet De Llobregat, Lleida, Madrid, Majadahonda, Málaga, Murcia, Pozuelo de Alarcón, Sevilla, Valencia, Valladolid, Vigo, Zaragoza
Age
18 years to 60 years
People
160 worldwide
Run by
Sanofi
See details and how to joinNCT07325292 · EU 2026-525688-41-00
Phase 2Taking people
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Where
Albacete, Barakaldo, Barcelona, L'hospitalet De Llobregat, Lleida, Madrid, Málaga, Murcia, Pozuelo de Alarcón, Salt, Santander, Santiago de Compostela, Sevilla, Valencia, Vigo
Age
18 years to 60 years
People
360 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07282574 · EU 2025-521636-10-00
No phaseNot yet taking people in Spain
Inductive Therapeutic Exercise in Multiple Sclerosis
Where
Madrid
Age
18 years and over
People
30
Run by
Fundación San Juan De Dios
See details and how to joinNCT07847853
Phase 3Taking people
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
Where
Barakaldo, Madrid, Oviedo, Sevilla
Age
Up to 17 years
People
64 worldwide
Run by
Novartis Pharma AG
See details and how to join2024-511686-11-00 · EU 2024-511686-11-00
Phase 3Taking people
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Where
Esplugues De Llobregat, Sevilla, Valencia, Vigo, Zaragoza
Age
10 years to 17 years
People
194 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06408259 · EU 2022-501332-42-00
No phaseNot yet taking people in Spain
[18F]F-DED PET Imaging of Reactive Astrocytes in Multiple Sclerosis
Where
Barcelona
Age
18 years to 65 years
People
30
Run by
Parc de Salut Mar
See details and how to joinNCT07805473 · EU 2026-525702-35-00
Phase 2Taking people
A Phase 2 Study of Obexelimab in Patients with Relapsing Multiple Sclerosis
Where
Madrid, Murcia, Sevilla, Valencia
Age
18 years to 64 years
People
93 worldwide
Run by
Zenas Biopharma (USA) LLC
See details and how to join2024-512707-40-00 · EU 2024-512707-40-00
No phaseTaking people
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Where
Madrid
People
908 worldwide
Run by
Biogen
See details and how to joinNCT05658497
No phaseTaking people
The Effect of a Probiotic Administration as an add-on Treatment in Multiple Sclerosis
Where
Barcelona
Age
18 years to 60 years
People
80
Run by
Hospital Universitari Vall d'Hebron Research Institute
See details and how to joinNCT07168772
No phaseNot yet taking people in Spain
Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis (MPIMS).
Where
Seville
Age
18 years to 80 years
People
84
Run by
Hospital Universitario Virgen Macarena
See details and how to joinNCT07741864
No phaseTaking people
Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III
Where
Pontevedra
Age
18 years and over
People
30
Run by
University of Vigo
See details and how to joinNCT07738120
Phase 3Taking people
A clinical trial to find out how well LOU064 (remibrutinib) works and how safe it is for people with secondary progressive multiple sclerosis
Where
Albacete, Alicante, Barakaldo, Barcelona, Castilleja De La Cuesta, Jerez de la Frontera, Las Palmas De Gran Canaria, L'hospitalet De Llobregat, Lleida, Logroño, Madrid, Málaga, Murcia, Pozuelo de Alarcón, Salamanca, Sevilla, Torrejón de Ardoz, Valencia
Age
18 years and over
People
677 worldwide
Run by
Novartis Pharma AG
See details and how to join2025-521546-23-00 · EU 2025-521546-23-00
No phaseTaking people
Mixed Reality for Upper Limb Rehabilitation in People With Multiple Sclerosis (VIRTUALDOMUS)
Where
Leganés
Age
18 years and over
People
30
Run by
Universidad Rey Juan Carlos
See details and how to joinNCT06968676
Phase 2Not yet taking people in Spain
A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis
Where
Badalona
Age
18 years to 65 years
People
14 worldwide
Run by
University Hospital, Antwerp
See details and how to joinNCT07020715 · EU 2025-522040-40-01
No phaseEnrolling by invitation
Effectiveness of Home-Based Exercise and Brain Stimulation for Reducing Fatigue in Patients With Multiple Sclerosis
Where
A Coruña, Santiago de Compostela, Vigo
Age
18 years to 75 years
People
60
Run by
Jacobo Formigo
See details and how to joinNCT07567989
No phaseTaking people
Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)
Where
Leganés
Age
18 years and over
People
20
Run by
Universidad Rey Juan Carlos
See details and how to joinNCT06795230