Tests stopping nasal rinses and steroids in cystic fibrosis patients
Tests stopping or continuing nasal saline rinses and steroids in adults with cystic fibrosis.
Plain-language title generated from the registry record
Registry title: Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Key facts
- Where
- Indianapolis, United StatesSee the site
- Phase
- Phase 3
Where in United States
- Indiana University HealthIndianapolis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Indiana University
- Trial code
- NCT06996951
- Record updated
- 10 November 2026
- Original description
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)Read full original descriptionShow less
Sinonasal Therapies and Histologic Correlations for Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
Inclusion: Age 18 or older; Cystic Fibrosis diagnosis on HEMT; History of chronic rhinosinusitis; Using topical nasal irrigations +/- additives (steroids, antibiotics).
Exclusion: Cystic Fibrosis patient NOT on highly effective modulator therapy; Not currently using topical nasal irrigations +/- additives (steroids, antibiotics); History of sinonasal or nasopharyngeal tumors; Active sinonasal infection or pulmonary infection; Oral antibiotics within last one month for upper respiratory or lower respiratory infection; Below age of 18 years old; Pregnant patients; Admission to hospital for pulmonary exacerbation within last 3 months.