Brief blocked blood flow in the thigh for knee osteoarthritis and low back pain
Tests temporary thigh blood flow restriction in people with knee osteoarthritis and low back pain.
Key facts
- Who runs it
- University of Illinois Chicago
- Where
- Chicago, United StatesSee the site
- Trial code
- Registry title
- Ischemic Preconditioning in Osteoarthritis and Back Pain
- Status
- Recruiting
- People taking part
- 24 people, planned
- Started
- 12 Sept 2025
- Expected to end
- 31 Dec 2026
- Type of study
- Interventional, 2 groupsOne group gets a sham (pretend) treatment, for comparison.
- Treatments tested
- Ischemic Preconditioning
- Sham Intervention
- Record updated
- 17 November 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 or older with knee osteoarthritis knee pain and low back pain. It tests briefly stopping blood flow in one thigh, compared with a sham (fake) treatment.
- Age
- 50 Years and older
- Sex
- All
- Disease stage
- Knee pain that meets the ACR criteria, and back pain with an ODI score > 12. You must be able to walk for at least 3 minutes without walking aids.
- Earlier treatment
- You cannot join if you had a knee or hip replacement, spine surgery, or a steroid injection within the previous 6 months.
Main reasons for not taking part
- Knee or hip replacement, or spine surgery in the past
- Blood clots in the leg, thrombosis, heart failure, or any condition where squeezing the thigh is unsafe
- A nerve and muscle condition that affects leg function
- Allergy to ultrasound gel
- Pregnant, planning a pregnancy during the study, or not an English speaker
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Reported Knee Pain using ACR Criteria
- Reported Back Pain using ODI Criteria > 12
- Ability to walk for at least 3 minutes without the use of aids
- Ability to provide written informed consent
Who cannot take part
- History of steroid injection within the previous 6 months
- History of Knee or Hip Replacements
- Presence of neuromuscular joint condition that affects lower extremity function
- History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
- History of heart failure or thrombosis
- Allergic to ultrasound gel
- History of spine surgery
- Younger than 50 years old
- Non-English speaker
- Currently pregnant or intends to become pregnant during the study
Where in United States
- Human and Sport Performance LabChicago, United StatesContact: Shraddha SudhirTaking people
About the trial
What the trial wants to find out
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
The 2 groups in the trial
- IC ArmTreatment being tested
Treatment: Ischemic Preconditioning
- Sham ArmSham treatment, for comparison
Treatment: Sham Intervention
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Ischemic Preconditioning in Osteoarthritis and Back Pain
- Plain-language title
- Brief blocked blood flow in the thigh for knee osteoarthritis and low back painGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 17 November 2025