Lifestyle changes to help prevent memory decline in people with depression
Tests diet, exercise and brain training in adults aged 50 to 80 with depression.
Plain-language title generated from the registry record
Registry title: Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice
Key facts
- Where
- Brescia, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 to 80 with depressive symptoms or major depression, but without signs of cognitive decline. It tests lifestyle changes: diet, exercise and cognitive training.
- Age
- 50 to 80 years
- Sex
- All sexes can join
- Disease stage
- Major depression diagnosed by DSM-5, or depressive symptoms (PHQ-9 or GDS-15 score of 5 or more). No dementia or cognitive impairment.
- Earlier treatment
- Cannot have used antibiotics or anti-inflammatory drugs in the 8 weeks before the screening visit.
Main reasons for not taking part
- Active gastrointestinal disorders
- Autoimmune disorders
- Chronic inflammatory disorders
- Dementia, cognitive impairment or mild functional impairment
- Antibiotics or anti-inflammatory drugs in the last 8 weeks
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT07009223, who can take part
Where in Italy
- IRCCS Centro San Giovanni di Dio FatebenefratelliBrescia, ItalyContact: Annamaria Cattaneo, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
- Trial code
- NCT07009223
- Record updated
- 11 February 2026
- Original description
The goal of this clinical study is to investigate if lifestyle changes can help prevent cognitive decline and reduce depressive symptoms in people between the ages of 50 and 80 with depressive symptoms or a diagnosis of major depression, but without signs of cognitive decline.Read full original descriptionShow less
Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice
The goal of this clinical study is to investigate if lifestyle changes can help prevent cognitive decline and reduce depressive symptoms in people between the ages of 50 and 80 with depressive symptoms or a diagnosis of major depression, but without signs of cognitive decline.
The main questions it aims to answer are:
* Does regular physical activity improve mood and memory in people who are depressed or have depressive symptoms? * Does cognitive training help prevent mental difficulties in people at risk of cognitive decline? * Do changes in diet and lifestyle alter the composition of the gut microbiota and immuno-related infiammatory factors?
Researchers will compare three different treatment groups to see which intervention is most effective in improving mental and cognitive health.
The participants:
* Will take part to online sessions on healthy eating based on the Mediterranean diet * Some will do regular exercise, supervised by a personal trainer * Others will do weekly cognitive training in small groups at the hospital * They will provide blood and fecal samples and complete cognitive tests and clinical questionnaires at the beginning, at the end of the treatment (12 weeks), and after 3 months.
Inclusion: Aged between 50 and 80 years; Diagnosis of DDM according to DSM-5 or depressive symptoms (PHQ-9 or GDS-15 ≥ 5, the choice of test will be justified by the participant's age); Ability to provide written informed consent.
Exclusion: Use of antibiotics and/or anti-inflammatory drugs in the 8 weeks prior to the screening visit; Active gastrointestinal disorders; Autoimmune disorders; Chronic inflammatory disorders; Diagnosis of dementia; cognitive impairment or mild functional impairment.