Fast Brain Stimulation Tested for Depression With Suicidal Thoughts in Young People
Tests fast magnetic brain stimulation in young people with depression and suicidal thoughts.
Plain-language title generated from the registry record
Registry title: Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
Key facts
- Where
- Sacramento, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 15 and 25 years old?
Source: NCT07025720, who can take part
Where in United States
- UC Davis Medical CenterSacramento, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Davis
- Trial code
- NCT07025720
- Record updated
- 11 March 2026
- Original description
The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts.Read full original descriptionShow less
Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts.
We want to see if:
1. This treatment is feasible and acceptable to patients 2. It can reduce depression and suicidal thoughts 3. It can lower the chance of going to the hospital 4. It affects daily functioning (school, work, relationships)
All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.
Inclusion: English speaking; Able to provide informed consent; age 15-25 years; Discharged within the past week from the ED for chief complaint of SI OR recently admitted in urgent health care setting or seen in outpatient clinic for depression-related suicidal ideation; Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI).
Exclusion: Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion; Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies; Contraindications to receiving TMS and/or MRI as determined by screening questionnaires; Unable to consent (due to medical condition, psychosis, substance use, etc); Active substance use or severe substance use that in the opinion of the PI would interfere with study participation; Untreated, active psychosis; Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study.