Taking people in United StatesNo phase

Exercise app with creatine and whey protein for frailty in cirrhosis

Tests an exercise app plus creatine and whey protein in people with cirrhosis.

Key facts

Who runs it: University of California, San Francisco
Where: San Francisco, United StatesSee the site
Trial code: NCT07029243
Registry title: Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis
Status: Recruiting
People taking part: 100 people, planned
Started: 15 Apr 2026
Expected to end: Dec 2026
Type of study: Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested: HEAL-ME digital app
Creatine supplementation
Whey protein supplementation
Placebo
Record updated: 15 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with cirrhosis (scarring of the liver). It tests an exercise and nutrition app with or without creatine and whey protein supplements.

Age: 18 Years and older
Sex: All sexes can join
Disease stage: Cirrhosis confirmed by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography (a liver stiffness scan).

Main reasons for not taking part

Allergy to milk protein
On hemodialysis
Not able to use English
Other severe illness that would stop you from finishing the study, in the investigator's view
Pregnant, breastfeeding, or planning to become pregnant during the study

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography
Access to digital device and internet at home
Ability to provide written informed consent before any study-related activities
Ability to remain in study for at least 3 months

Who cannot take part

Concomitant severe underlying systemic illness that in the opinion of the Investigator would interfere with completion of study
Allergy to milk protein
Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data
On hemodialysis
No English language proficiency
Pregnant, breastfeeding, or intention of becoming pregnant during study time frame

Where in United States

University of California San FranciscoSan Francisco, United StatesContact: Melinda Wang, MD, MHSTaking people

About the trial

What the trial wants to find out

Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition/exercise prehabilitation app will maintain muscle health in patients with liver disease.

The 2 groups in the trial

HEAL-ME and placebo supplementationPlacebo, for comparison
Patients within this arm will be administered the HEAL-ME digital app and placebo supplementation daily
Treatment: HEAL-ME digital app and Placebo
HEAL-ME and creatine/whey protein supplementationTreatment being tested
Patients within this arm will be administered the HEAL-ME digital app and whey protein/creatine combination supplementation daily
Treatment: HEAL-ME digital app, Creatine supplementation, and Whey protein supplementation