Tests a digital brain and movement program for memory decline
Tests digital brain and movement training in people with mild memory problems or Alzheimer's.
Plain-language title generated from the registry record
Registry title: The COMFORTage Project at Ace Alzheimer Center Barcelona
Key facts
- Where
- Barcelona, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 60 to 85 with mild cognitive impairment or mild Alzheimer's dementia who can use digital tools and attend regular in-person sessions in Barcelona.
- Age
- 60 to 85 years
- Sex
- All sexes can join.
- Disease stage
- Mild cognitive impairment (MCI) with a CDR score of 0.5, or mild Alzheimer's dementia with a CDR score of 1.
Main reasons for not taking part
- History of traumatic brain injury
- Severe depression
- History of stroke or brain tumors
- Significant visual or hearing problems that are not corrected
- No digital device or internet connection
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 85 years old?
Source: NCT07031167, who can take part
Where in Spain
- Ace Alzheimer Centre Barcelona (Fundació ACE)Barcelona, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundació ACE Institut Català de Neurociències Aplicades
- Trial code
- NCT07031167
- Record updated
- 22 June 2025
- Original description
The COMFORTage study at Ace Alzheimer Center Barcelona is investigating whether a personalized cognitive and functional stimulation program can help slow cognitive decline in individuals diagnosed with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD) dementia.Read full original descriptionShow less
The COMFORTage Project: Integration of Multiple Sources Towards Personalized Preventions at Ace Alzheimer Center Barcelona
The COMFORTage study at Ace Alzheimer Center Barcelona is investigating whether a personalized cognitive and functional stimulation program can help slow cognitive decline in individuals diagnosed with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD) dementia.
The study involves 100 participants aged 60 to 85, who are randomly assigned to one of two groups. The active group receives weekly in-person sessions for one year, featuring individualized cognitive and physical training through digital platforms developed by the COMFORTage project. The control group does not participate in the training but undergoes the same schedule of health assessments and monitoring.
All participants are followed for a total of two years. Throughout the study, researchers collect comprehensive clinical, neuropsychological, and biological data. This includes cognitive assessments, magnetic resonance imaging (MRI) brain scans, blood and cerebrospinal fluid (CSF) samples, and genetic testing. In addition, participants complete spontaneous speech recordings from home every 3-4 months using a dedicated mobile application.
The primary objective is to determine whether the stimulation program more effectively preserves memory and cognitive function compared to no intervention. The study also evaluates its impact on physical and emotional well-being, daily functioning, and quality of life. Insights from the trial will contribute to the development of an artificial intelligence (AI)-powered digital health platform aimed at delivering personalized care for individuals living with dementia.
Inclusion: Age between 60 and 85 years; Diagnosis of MCI based on Petersen criteria with a CDR score of 0.5; Diagnosis of mild AD dementia according to National Institute on Aging-Alzheimer's Association (NIA-AA) criteria with a CDR score of 1; Proficiency in using digital tools such as mobile apps, tablets, or computers; Ability and willingness to attend regular in-person sessions at Ace Alzheimer Center Barcelona; Provided written informed consent after receiving a full explanation of the study.
Exclusion: History of traumatic brain injury; History of stroke or brain tumors; Any medical condition that may confound cognitive assessment or limit participation; Diagnosis of severe depression; Presence of significant uncorrected visual or auditory impairments; Lack of access to a digital device or internet connection; Inability to participate in regular in-person sessions at the study site.