Alzheimer disease trials in Spain

In Spain 58 Also abroad 815

58 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
A Study of Treatments for the Prevention of Disease Progression in Individuals at Risk for or With Early Onset Alzheimer’s Disease Caused by a Genetic Mutation
Where
Barcelona
Age
18 years and over
People
27 worldwide
Run by
Washington University School Of Medicine
See details and how to join2024-517187-36-01 · EU 2024-517187-36-01
Phase 3Taking people
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Where
Elche, Getxo, Madrid, Málaga, Pamplona, Salamanca, Sevilla, Terrassa, Valladolid, Zaragoza
Age
55 years to 90 years
People
426 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07011732 · EU 2025-520613-31-00
No phaseTaking people
InRAD Observational Study
Where
Barcelona
Age
18 years and over
People
50,000 worldwide
Run by
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation
See details and how to joinNCT07213700
Phase 2/3Taking people
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia
Where
Badalona, Madrid, Sevilla, Valladolid, Zamora
Age
55 years to 90 years
People
300 worldwide
Run by
Exciva GmbH
See details and how to joinNCT07284472 · EU 2024-517388-22-00
Phase 2Taking people
A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
Where
Barcelona, Pozuelo de Alarcón, Valencia, Zaragoza
Age
55 years to 85 years
People
160 worldwide
Run by
Sanofi
See details and how to joinNCT07688213 · EU 2025-524581-14-00
Phase 2Taking people
Study to Test Effects and Safety of RO7568282 in Early Symptomatic Alzheimer's Disease
Where
Barcelona, Donostia, Madrid, Valencia
Age
50 years to 90 years
People
450 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07781657 · EU 2026-526158-14-00
Phase 2/3Taking people
ACP-204 in Adults With Alzheimer's Disease Psychosis
Where
Badalona, Málaga, Sevilla, Zamora
Age
55 years to 95 years
People
1,074 worldwide
Run by
ACADIA Pharmaceuticals Inc.
See details and how to joinNCT06159673 · EU 2023-507325-42-00
No phaseNot yet taking people in Spain
Exercise in Alzheimer's Disease: Functional Biomarkers
Where
Valladolid
Age
60 years and over
People
48
Run by
European University Miguel de Cervantes
See details and how to joinNCT07918417
Phase 3Enrolling by invitation
ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study
Where
Badalona, Málaga, Sevilla, Zamora
Age
55 years to 95 years
People
752 worldwide
Run by
ACADIA Pharmaceuticals Inc.
See details and how to joinNCT06194799 · EU 2023-507351-29-00
Phase 2Taking people
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
Where
Albacete, Zamora, Zaragoza
Age
55 years and over
People
370 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06540833
Phase 2Taking people
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
Where
Albacete, Badalona, Getafe, Málaga, Zamora, Zaragoza
Age
55 years and over
People
320 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06651567 · EU 2024-514680-26-00
Phase 3Taking people
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Where
Lleida, Madrid, Majadahonda, Málaga, Salamanca, Sevilla, Valladolid, Zaragoza
Age
55 years to 90 years
People
406 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT06585787 · EU 2024-516363-92-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Where
Barcelona, Lleida, Madrid, Pamplona, Sant Cugat del Vallès, Sevilla
Age
60 years to 85 years
People
586 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06976216 · EU 2025-520746-30-00
Phase 2Taking people
Sleep and body temperature as markers of progression of Alzheimer's disease in Down syndrome.
Where
Barcelona
Age
18 years to 64 years
People
60
Run by
Fundacio Institut De Recerca De L Hospital De La Santa Creu I Sant Pau
See details and how to join2023-506609-21-00 · EU 2023-506609-21-00
Phase 2Taking people
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Where
Barcelona, Terrassa
Age
50 years to 85 years
People
340 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07033494 · EU 2024-519190-19-00
Phase 3Taking people
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Where
Barcelona, Córdoba, Denia, Donosti-San Sebastián, Granada, Madrid, Martorell, Pozuelo de Alarcón, Seville, Terrassa, Valencia
Age
50 years to 90 years
People
80,000 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07177352
Phase 3Taking people
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
Where
Madrid, Majadahonda, Málaga, Salamanca, Sevilla, Valladolid, Zamora, Zaragoza
Age
55 years to 90 years
People
1,000 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT05980949 · EU 2023-504151-27-00
Phase 3Taking people
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
Where
Elche, Getxo, Madrid, Málaga, Pamplona, Salamanca, Sevilla, Terrassa, Valladolid, Zaragoza
Age
55 years to 90 years
People
650 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06937229 · EU 2024-519994-20-00
Phase 2Taking people
A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
Where
Barcelona, Dos Hermanas, Madrid, Málaga, Pamplona, Valencia
Age
40 years to 55 years
People
58 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07636811 · EU 2025-523390-42-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
Where
Barcelona, Donostia, Madrid, Pozuelo de Alarcón, Santander, Valencia
Age
60 years to 85 years
People
586 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06976203 · EU 2025-520747-32-00
Phase 1Taking people
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Where
Barcelona, Madrid, Sant Cugat del Vallès
Age
40 years to 80 years
People
50 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07214727 · EU 2025-522582-30-00
No phaseTaking people
Dominantly Inherited Alzheimer Network (DIAN)
Where
Barcelona
Age
18 years and over
People
700 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT00869817
Phase 3Not yet taking people in Spain
A study to learn about the effects of Trontinemab in participants at risk for Alzheimer‘s disease
Where
Barcelona, Donostia, Lleida, Madrid, Pamplona, Pozuelo de Alarcón, Santander, Sant Cugat del Vallès, Sevilla, Valencia
Age
18 years and over
People
119 worldwide
Run by
F. Hoffmann-La Roche AG
See details and how to join2025-524314-29-00 · EU 2025-524314-29-00
No phaseNot yet taking people in Spain
Neuroprotective Effects of Oleanolic Acid and Erythrodiol in Prodromal Alzheimer's Disease
Where
Seville
Age
50 years to 80 years
People
120
Run by
Spanish National Research Council
See details and how to joinNCT07847944
No phaseTaking people
Personalized Brain Health Service and Dementia Prevention
Where
Barcelona
Age
55 years to 85 years
People
120
Run by
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
See details and how to joinNCT07698431