Studies how upper body fat tissue responds to a meal in obesity
Compares fat tissue release after a meal in people with obesity and normal weight.
Key facts
- Who runs it
- Mayo Clinic
- Where
- Rochester, United StatesSee the site
- Trial code
- Registry title
- Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
- Status
- Recruiting
- People taking part
- 20 people, planned
- Started
- 5 May 2026
- Expected to end
- May 2028
- Type of study
- Interventional, 2 groups
- Treatments tested
- Meal Study
- Record updated
- 5 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 55 with normal weight or with obesity. Women must be before menopause.
- Age
- 18 to 55 years
- Sex
- Men and women can join. All women must be premenopausal.
- Earlier treatment
- People taking medicines that affect blood flow (statins, β-blockers) or fat metabolism (TZDs, high dose fish oil supplements) cannot join.
Main reasons for not taking part
- Taking medicines that affect blood flow (statins, β-blockers)
- Taking medicines that affect fat metabolism (TZDs, high dose fish oil supplements)
- Diabetes or a history of cardiovascular disease
- Allergy to lidocaine
- Post-menopausal women or pregnant women
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- All women must be premenopausal
Who cannot take part
- Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
- Diabetes, history of cardiovascular disease
- Allergy to lidocaine
- Post-menopausal women
- Pregnant
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Where in United States
- Mayo Clinic in RochesterRochester, United StatesContact: Kelli A Lytle (principal investigator)Taking people
About the trial
What the trial wants to find out
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.
The 2 groups in the trial
- Normal weight groupOther group
5 male and 5 female volunteers in normal weight range
Treatment: Meal Study
- Obesity groupOther group
5 male and 5 female volunteers with obesity (BMI 29.0-35.0 kg/m2)
Treatment: Meal Study
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Upper Body Subcutaneous Adipose Tissue Outflow Response to a Meal
- Plain-language title
- Studies how upper body fat tissue responds to a meal in obesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07031297, who can take part
- Record updated
- 5 August 2026