Testing combinations of eating strategies in an online weight loss program for adults

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with overweight or obesity who live in the United States and want to lose weight through behavioral strategies. It is a fully remote 12-week digital program.

Age

18 years or older

Sex

All sexes can join

Disease stage

Body mass index (BMI) of 25.0 to 45.0 kg/m^2

Earlier treatment

Cannot join if currently using a weight loss or anti-obesity medication, if enrolled in another weight management program, or if they lost 5% or more of body weight in the past 6 months. Prior or planned bariatric surgery in the next 3 months also rules out joining.

Main reasons for not taking part

• Current, planned (next 3 months) or recent (past 6 months) pregnancy, or current breastfeeding
• Hospitalization for a mental health condition in the past 12 months
• Cannot do moderate physical activity such as brisk walking
• Health condition or medicine that makes weight loss unsafe or affects it (for example end stage renal disease, cancer, schizophrenia, dementia, steroids, antipsychotics)
• History of an eating disorder or cardiovascular event, uncontrolled hypertension, or uncontrolled diabetes mellitus

The registry criteria, word for word

What the trial wants to find out

The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback.

The 16 groups in the trial

• Condition 1Treatment being tested

  Core Only

  Treatment: Core Behavioral Weight Loss Intervention

• Condition 2Treatment being tested

  Core + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention and Increase Fiber Intake

• Condition 3Treatment being tested

  Core + Increase Protein

  Treatment: Core Behavioral Weight Loss Intervention and Increase Protein

• Condition 4Treatment being tested

  Core + Increase Protein + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Increase Protein, and Increase Fiber Intake

• Condition 5Treatment being tested

  Core + Limit Eating Window

  Treatment: Core Behavioral Weight Loss Intervention and Limit Eating Window

• Condition 6Treatment being tested

  Core + Limit Eating Window + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Eating Window, and Increase Fiber Intake

• Condition 7Treatment being tested

  Core + Limit Eating Window + Increase Protein

  Treatment: Core Behavioral Weight Loss Intervention, Limit Eating Window, and Increase Protein

• Condition 8Treatment being tested

  Core + Limit Eating Window + Increase Protein + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Eating Window, Increase Protein, and Increase Fiber Intake

• Condition 9Treatment being tested

  Core + Limit Red Zone Foods

  Treatment: Core Behavioral Weight Loss Intervention and Limit Red Zone Foods

• Condition 10Treatment being tested

  Core + Limit Red Zone Foods + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, and Increase Fiber Intake

• Condition 11Treatment being tested

  Core + Limit Red Zone Foods + Increase Protein

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, and Increase Protein

• Condition 12Treatment being tested

  Core + Limit Red Zone Foods + Increase Protein + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Increase Protein, and Increase Fiber Intake

• Condition 13Treatment being tested

  Core + Limit Red Zone Foods + Limit Eating Window

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, and Limit Eating Window

• Condition 14Treatment being tested

  Core + Limit Red Zone Foods + Limit Eating Window + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Limit Eating Window, and Increase Fiber Intake

• Condition 15Treatment being tested

  Core + Limit Red Zone Foods + Limit Eating Window + Increase Protein

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Limit Eating Window, and Increase Protein

• Condition 16Treatment being tested

  Core + Limit Red Zone Foods + Limit Eating Window + Increase Protein + Increase Fiber

  Treatment: Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Limit Eating Window, Increase Protein, and Increase Fiber Intake