Tests low-dose radiotherapy for people with heart failure
Tests a single low-dose radiation treatment to the whole heart in adults with heart failure.
Plain-language title generated from the registry record
Registry title: Low Dose Radiotherapy for Heart Failure
Key facts
- Where
- São Paulo, BrazilSee the site
- Phase
- Phase 1/2
Where in Brazil
- Hcor / Associação Beneficente SíriaSão Paulo, BrazilNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital do Coracao
- Trial code
- NCT07037524
- Record updated
- 25 June 2025
- Original description
The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.Read full original descriptionShow less
Prospective Pilot Single-center Study to Evaluate the Safety and Efficacy of Low-dose Radiotherapy in Patients With Heart Failure
The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.
Inclusion: Age >18 years; Clinical and laboratory diagnosis of chronic systolic HF grades II or III of the New York Heart Association with ejection fraction <40%; Refractoriness to standard clinical treatment; defined as the persistence of HF signs and symptoms despite optimized drug therapy; Patient consent to participate in the study; Agreement to adopt contraceptive practices/methods until the end of the intervention for women of childbearing age.
Exclusion: Patients who have undergone any type of previous radiotherapy in the thoracic region; Contraindications for magnetic resonance imaging (MRI), such as the use of metal implants or prostheses; Patients who have undergone heart transplants; Pregnant patients.