Testing a Brain Skills Evaluation in Adults With Down Syndrome
Tests a brain skills evaluation in adults with Down syndrome.
Plain-language title generated from the registry record
Registry title: Neuropsychological Evaluation in Intellectual Disability (ENDI)
Key facts
- Where
- Vandœuvre-lès-Nancy, FranceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 25 to 65. In the main phase these are people with Down syndrome (trisomy 21). In the first phase it also includes volunteers without disability and people with intellectual disability.
- Age
- 25 to 65 years
- Sex
- All sexes
- Disease stage
- Main phase: a person with trisomy 21. First phase: people with intellectual disability noted in medical records, or volunteers without disability.
- Earlier treatment
- No change in long-term medication in the 8 weeks before the evaluation.
Main reasons for not taking part
- Motor or sensory problems that stop the person from doing the tests
- Not enough French to do the tests
- Severe general medical illness or alcoholism
- History of stroke, severe head injury or cancer
- Pregnant, in labor or breastfeeding women; people deprived of liberty by a court or authority decision
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 65 years old?
Source: NCT07047963, who can take part
Where in France
- CHRU de NancyVandœuvre-lès-Nancy, FranceContact: Amélie COQUELET, PsychologistNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Central Hospital, Nancy, France
- Trial code
- NCT07047963
- Record updated
- 2 July 2025
- Original description
The goal of this observational study is to evaluate the acceptability ofpatients with trisomy 21 (T21) to perform the full battery of ENDI neurospychological tests and each of the subsets.Read full original descriptionShow less
Neuropsychological Evaluation in Intellectual Disability
The goal of this observational study is to evaluate the acceptability ofpatients with trisomy 21 (T21) to perform the full battery of ENDI neurospychological tests and each of the subsets.
In this study, three types of population will be recruted : normotypic volunteers, patients with Intellectual Disability and patients T21carriers.
This study is separated into 2 phases :
* A the preliminary phase : this phase will be used to evaluate subtest design, ergonomics and understanding of instructions, and to identify any malfunctions. The observations gathered will enable the principal investigator to refine the digital design of the battery in collaboration with the publishing company. In this phase, normotypical volunteers and patients with intellectual disabilities will be recruted to perform ENDI test battery. * A main phase : this phase will enable to answer to the main objective. in this phase, patients with Trisomy 21 aged between 25 and 65 will be recruted to perform ENDI test battery.
Inclusion: Preliminary phase:; The inclusion criteria for the group of people with intellectual disabilities are as follows:; Participant who has received full information on the organization of the research and has not objected to his or her participation and to the use of his or her data; Legal guardian of the participant, if applicable, who has received full information on the organization of the research and has not objected to participation and use of his/her data; Age at inclusion: ≥ 25 and ≤ 65 years; Notion of intellectual disability in medical records; Access to the oral language of the participant with an intellectual disability: the subject's speech must be comprehensible to the evaluator and the subject must be able to understand simple statements. It is not possible to use an oral comprehension test (e.g. Token test by Renzi \& Vignolo, 1962), as the norms achieved in healthy subjects would exclude almost all patients with intellectual disabilities, who have more limited language skills; Enrolled in or benefiting from a social security scheme; The inclusion criteria for the normotypic group are as follows:; Participant having received full information on the organization of the research and not having objected to his or her participation and to the use of his or her data; Age at inclusion: ≥ 25 and ≤ 65 years; Affiliation with a social security scheme or beneficiary of such a scheme; Main phase:; Participant with T21 who has received full information on the organization of the research and has not objected to participation and use of his/her data; Legal guardian of the participant with T21, where applicable, who has received full information on the organization of the research and has not objected to his or her participation and the use of his or her data; Person with trisomy 21; Age at inclusion: ≥ 25 and ≤ 65 years; Access to the oral language of the participant with T21: the subject's speech must be comprehensible to the evaluator and the subject must be able to understand simple statements. It is not possible to use an oral comprehension test (e.g. Token test by Renzi \& Vignolo, 1962), as the norms achieved in healthy subjects would exclude almost all patients with intellectual disabilities, who have more limited language skills; Membership of a social security scheme or beneficiary of such a scheme.
Exclusion: Change in long-term medication within 8 weeks prior to evaluation; Severe general medical condition or alcoholism (habitual consumption of 3 drinks/day or history of alcohol withdrawal); History of stroke, severe head trauma, or cancer; Individuals referred to in Articles L.1121-5 to L.1121-7 of the French Public Health Code:; Pregnant women, women in labor, or breastfeeding mothers; Individuals deprived of liberty by judicial or administrative decision; Individuals undergoing psychiatric treatment under Article L.3213-1 of the French Public Health Code; Disabling motor and/or sensory impairments preventing completion of the tests; Insufficient command of the French language to complete the tests; Refusal to participate by the subject and/or legal representative.