Online therapy with a psychologist's support for women with depression
Tests an internet-based talk therapy course in women with moderate depression.
Plain-language title generated from the registry record
Registry title: Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes
Key facts
- Where
- Barcelona, SpainSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT07060690, who can take part
Where in Spain
- Hospital del Mar Research InstituteBarcelona, SpainNot yet recruiting
- Parc de Recerca Biomèdica de BarcelonaBarcelona, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Francesc Colom, PsyD, PhD
- Trial code
- NCT07060690
- Record updated
- 9 October 2026
- Original description
This study aims to evaluate the efficacy of a specially developed internet-based Cognitive Behavioural Therapy (CBT) programme with human interaction-referred to as the 3D programme-tailored specifically for women experiencing moderate depressive symptoms. We hypothesise that participation in the intervention will lead to greater improvements in depression severity, compared to receiving only brief psychoeducational videos, when used as an add-on to treatment as usual (TAU) in this population.Read full original descriptionShow less
A Women-Centered Approach: Evaluating a Human-Supported Online Intervention for Depression. Study on Its Efficacy and the Metabolic Signature of Personalised Treatment Response
This study aims to evaluate the efficacy of a specially developed internet-based Cognitive Behavioural Therapy (CBT) programme with human interaction-referred to as the 3D programme-tailored specifically for women experiencing moderate depressive symptoms. We hypothesise that participation in the intervention will lead to greater improvements in depression severity, compared to receiving only brief psychoeducational videos, when used as an add-on to treatment as usual (TAU) in this population.
The 3D programme is a 10-week blended intervention that includes ten weekly online self-guided modules focused on depression and women's health, along with six individual video sessions with a health/clinical psychologist. The modules cover topics such as mood changes across the menstrual cycle, body image, stress, caregiving, and the impact of gender-based experiences on mental health.
To explore how biological factors may influence how participants respond to treatment, the study will collect biological samples. These will be analysed to track hormone and metabolic changes, with the goal of identifying biological markers that might predict who benefits most from the intervention.
Ultimately, the results of this study aim to improve access to effective and personalised mental health care for women by evaluating whether a structured and personalised online CBT programme can provide meaningful benefits.
Inclusion: Women; Age between 18 and 45 years (inclusive); Moderate depressive symptoms, defined by a score of 17 to 23 on the 17-item Hamilton Depression Rating Scale (HDRS-17); Fluent in Spanish; Access to the internet and the ability to use digital devices (e.g., smartphone, tablet, or computer).
Exclusion: Currently receiving psychological therapy; Cognitive impairment that may interfere with informed consent or study participation; Presence of psychotic symptoms, active suicidal ideation, or current substance abuse disorder; Participation in any other interventional clinical trial for depression within the past 3 months; Pregnant or planning to become pregnant during the study period.